Listar por autoría "c3942d90-db12-4fc8-985d-cf21260ea60d"
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Bioelectrical Signals and Ion Channels in the Modeling of Multicellular Patterns and Cancer Biophysics
Cervera, Javier; Alcaraz, Antonio; Mafe, Salvador Nature Publishing Group (2016)Bioelectrical signals and ion channels are central to spatial patterns in cell ensembles, a problem of fundamental interest in positional information and cancer processes. We propose a model for electrically connected ... -
Divalent cations reduce the pH sensitivity of OmpF channel inducing the pKa shift of key acidic residues
Queralt-Martín, María; Alcaraz, Antonio; García Giménez, Elena; Mafe, Salvador RSC Publishing (2010-11-03)In contrast to the highly-selective channels of neurophysiology employing mostly the exclusion mechanism, different factors account for the selectivity of large channels. Elucidation of these factors is essential for ... -
Electrical pumping of potassium ions against an external concentration gradient in a biological ion channel
Aguilella, Vicente; Alcaraz, Antonio; Ramírez, Patricio; García Giménez, Elena; Mafe, Salvador; Queralt-Martín, María AIP Publishing (2013-07-22)We show experimentally and theoretically that significant currents can be obtained with a biological ion channel, the OmpF porin of Escherichia coli, using zero-average potentials as driving forces. The channel rectifying ... -
Energy transduction and signal averaging of fluctuating electric fields by a single protein ion channel
Verdiá Báguena, Carmen; Gómez, V.; Cervera, Javier; Ramírez, Patricio; Mafe, Salvador Royal Society of Chemistry (2017)We demonstrate the electrical rectification and signal averaging of fluctuating signals using a biological nanostructure in aqueous solution: a single protein ion channel inserted in the lipid bilayer characteristic of ... -
Entropy–enthalpy compensation at the single protein level: pH sensing in the bacterial channel OmpF
Alcaraz, Antonio; Queralt-Martín, María; Verdiá Báguena, Carmen; Aguilella, Vicente; Mafe, Salvador The Royal Society of Chemistry (2014)The pH sensing mechanism of the OmpF channel operates via ligand modification: increasing acidity induces the replacement of cations with protons in critical binding sites decreasing the channel conductance. Aside from the ... -
Membrane Potential Bistability in Nonexcitable Cells as Described by Inward and Outward Voltage-Gated Ion Channels
Cervera, Javier; Alcaraz, Antonio; Mafe, Salvador American Chemical Society (2014-10)The membrane potential of nonexcitable cells, defined as the electrical potential difference between the cell cytoplasm and the extracellular environment when the current is zero, is controlled by the individual electrical ... -
Memristive arrangements of nanofluidic pores
Ramirez, Patricio; Portillo Pous, Sergio; Cervera, Javier; Bisquert, Juan; Mafe, Salvador American Physical Society (2024-04-24)We demonstrate that nanofluidic diodes in multipore membranes show a memristive behavior that can be controlled not only by the amplitude and frequency of the external signal but also by series and parallel arrangements ... -
Synaptical Tunability of Multipore Nanofluidic Memristors
Ramirez, Patricio; Gómez, Vicente; Cervera, Javier; Mafe, Salvador; Bisquert, Juan American Chemical Society (ACS) (2023-11-27)We demonstrate a multipore nanofluidic memristor with conical pores showcasing a wide range of hysteresis and memristor properties that provide functionalities for brain-like computation in neuromorphic applications. ...