Listar por autoría "b453ce7f-649d-4814-aaa3-7dd545e497eb"
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Deterioros motores producidos por los antipsicóticos típicos en muestras de ratones adultos jóvenes y viejos: Efecto terapeútico de los antagonistas de adenosina cafeína, teofilina y MSX-3
López Cruz, Laura; Fuentes-Claramonte, Paola; Pardo, Marta; Caballer, Gemma; Salamone, John; Correa, Merce Universitat Jaume I (2008)Uno de los efectos colaterales de la administración de neurolépticos para el tratamiento de los síntomas de la esquizofrenia es la afectación motora. Los antagonistas dopaminérgicos como el haloperidol, ampliamente ... -
Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: Studies using medium to high doses in animal models
López Cruz, Laura; Pardo Andrés, Marta; Salamone, John; Correa, Merce Elsevier (2014-08)Rationale: Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which ... -
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes, Eric J.; Randall, Patrick A.; Santerre, Jessica L.; Given, A. B.; Sager, Thomas Nikolaj; Correa, Merce; Salamone, John Elsevier (2010)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from ... -
Dopamine and Food Addiction: Lexicon Badly Needed
Salamone, John; Correa, Merce Elsevier (2013-05-01)Over the last few years, the concept of food addiction has become a common feature in the scientific literature, as well as the popular press. Nevertheless, the use of the term addiction to describe pathological aspects ... -
Dopamine depletion shifts behavior from activity based reinforcers tomore sedentary ones and adenosine receptor antagonism reversesthat shift: Relation to ventral striatum DARPP32 phosphorylationpatterns
López Cruz, Laura; SanMiguel, Noemí; Carratalá-Ros, Carla; Monferrer Sales, Lidón; Salamone, John; Correa, Merce Elsevier (2018)The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-baseddecision-making. DA depletion produces anergia (shifts to low effort options) in animals tested oneffort-based decision-making ... -
Dopamine, behavioral economics, and effort
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Pardo Andrés, Marta Frontiers Research Foundation (2009)There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as ... -
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
Salamone, John; Correa, Merce; Yang, Jen-Hau; Rotolo, Renee; Presby, Rose Frontiers Media (2018-03)Operant behavior is not only regulated by factors related to the quality or quantity of reinforcement, but also by the work requirements inherent in performing instrumental actions. Moreover, organisms often make ... -
Dopamine/adenosine interaction in effort-related processes in rodents: Studies using T-Maze paradigm in mice
Pardo, Marta; Ordaz, G.; Salamone, John; Correa, Merce Universitat Jaume I (2008)Humans and animals realize cost/benefits analysis of our responses with the goal of use the lowest energy possible to obtain the major benefit. Mesolimbic dopamine (DA) is a critic component in the cerebral circuitry ... -
Dopamine/adenosine interactions involved in effort-related aspects of food motivation
Salamone, John; Correa, Merce Elsevier (2009)Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of ... -
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
Salamone, John; Ishiwari, K.; Betz, Adrienne J.; Farrar, Andrew M.; Mingote, Susana; Font Hurtado, Laura; Hockemeyer, J.; Müller, Christa E.; Correa, Merce Elsevier (2008)Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Dosis medias y altas de cafeína no revierten la incoordinación motora producida por alcohol en ratones
San Miguel Segura, Noemí; López Cruz, Laura; Pardo Andrés, Marta; Correa, Merce Universitat Jaume I (2015)En los últimos años, el consumo de las bebidas energéticas ha incrementado notablemente, así como su concentración de cafeína. Con frecuencia, estas bebidas se consumen junto a grandes cantidades de alcohol con el objetivo ... -
Efecto ansiogénico del disulfiram en animales tratados con alcohol: Relevancia en la terapia farmacológica antialcohólica
Escrig, Miguel A.; Pardo, Marta; González, Carlos M.; Correa, Merce Universitat Jaume I (2006)El alcohol etílico, a dosis moderadas, produce efectos ansiolíticos, tanto en humanos como en roedores. Sin embargo, la acumulación de acetaldehído (primer metabolito del alcohol) en el organismo, está considerada aversiva ... -
Efecto ansiogénico y supresión motora inducidos por dosis altas de cafeína: Estudio en modelos animales
López Cruz, Laura; Pardo, Marta; Dosda, Alicia; Correa, Merce Universitat Jaume I (2009) -
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2013-06-15)Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing, psychostimulants promote exploration. Minor stimulants such as caffeine, ... -
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
Yohn, Samantha E.; López Cruz, Laura; Hutson, Peter H.; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, ... -
Effects of the adenosine A2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide
Betz, Adrienne J.; Vontell, Regina; Valenta, J.; Worden, Lila T.; Sink, Kelly S.; Font Hurtado, Laura; Correa, Merce; Sager, Thomas Nikolaj; Salamone, John Elsevier (2009-09)Typical antipsychotic drugs, including haloperidol and pimozide, have been shown to produce parkinsonian motor effects such as akinesia and tremor. Furthermore, there is an antagonistic interaction between adenosine A2A ... -
Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice : sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles
Carratalá Ros, Carla; Martínez‑Verdú, Andrea; Olivares-García, Régulo; Salamone, John; Correa, Merce Springer Nature (2023-07-05)Background ; Depression is a disorder twice as common in women than in men. There are sex differences in the symptomatology and treatment response to this disorder. Impairments in behavioral activation (i.e. anergia, ... -
Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
Yang, Jen-Hau; Presby, Rose; Cayer, Suzanne; Rotolo, Renee; Perrino, Peter A.; Fitch, R. Holly; Correa, Merce; Chesler, Elissa J.; Salamone, John Elsevier (2020)Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Salamone, John; Estrada, Alexavier; Epling, Brian; Hart, Evan E.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis Springer (2014-02)Rationale. Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of ...