Listar por autoría "98a22790-da73-440a-892b-8c7940663da1"
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A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity
MIQUEL, MARTA; Nicola, Saleem; Gil-Miravet, Isis; Guarque-Chabrera, Julian; Sanchez-Hernandez, Aitor Frontiers Media (2019-05)Growing evidence associates cerebellar abnormalities with several neuropsychiatric disorders in which compulsive symptomatology and impulsivity are part of the disease pattern. Symptomatology of autism, addiction, ... -
Cerebellar hallmarks of conditioned preference for cocaine
Carbó Gas, María; Vázquez Sanromán, Dolores; Gil-Miravet, Isis; De las Heras-Chanes, Joan; Coria Ávila, Genaro A.; Manzo, Jorge; Sanchis-Segura, Carla; MIQUEL, MARTA Elsevier (2014)Pavlovian conditioning tunes the motivational drive of drug-associated stimuli, fostering the probability of those environmental stimuli to promote and trigger drug seeking and taking. Interestingly, different areas in ... -
Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site matters
Carbó Gas, María; Moreno Rius, Josep; Guarque-Chabrera, Julian; Vázquez Sanromán, Dolores; Gil-Miravet, Isis; Carulli, Daniela; Hoebeek, Freek; De Zeeuw, Chris; Sanchis-Segura, Carla; MIQUEL, MARTA Elsevier (2017-07-14)One of the key mechanisms for the stabilization of synaptic changes near the end of critical periods for experience-dependent plasticity is the formation of specific lattice extracellular matrix structures called perineuronal ... -
Cocaine-induced plasticity in the cerebellum of sensitised mice
Vázquez Sanromán, Dolores; Carbó Gas, María; Leto, Ketty; Cerezo García, Miguel; Gil-Miravet, Isis; Sanchis-Segura, Carla; Carulli, Daniela; Rossi, Ferdinando; MIQUEL, MARTA Springer Verlag (2015)Rationale Prior research has accumulated a substantial amount of evidence on the ability of cocaine to produce short- and long-lasting molecular and structural plasticity in the corticostriatal-limbic circuitry. However, ... -
Cocaine-Induced Preference Conditioning: a Machine Vision Perspective
Traver Roig, Vicente Javier; Pla, Filiberto; MIQUEL, MARTA; Carbó Gas, María; Gil-Miravet, Isis; Guarque-Chabrera, Julian Springer (2018)Existing work on drug-induced synaptic changes has shown that the expression of perineuronal nets (PNNs) at the cerebellar cortex can be regulated by cocaine-related memory. However, these studies on animals have mostly ... -
Datasets from: Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization, and septal-gating of temporal lobe theta rhythm activity
Gil-Miravet, Isis; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Ros Bernal, Francisco; Gundlach, Andrew Lawrence; Nuñez Molina, Angel; Olucha-Bordonau, Francisco E (2023) -
Ejercicio físico y cognición: una revisión sistemática de estudios experimentales en ancianos
Gil-Miravet, Isis Universitat Jaume I (2019-10-15)The life expectancy increasement has led to cognitive impairment becoming a major concern of the world population. This impairment greatly limits the quality of life of the elderly, generating important functional ... -
From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues
Gil-Miravet, Isis; Melchor Eixea, Ignasi; Arias-Sandoval, Edgar; Vasquez‐Celaya, Lizbeth; Olucha-Bordonau, Francisco E; MIQUEL, MARTA Wiley (2019)It is now increasingly clear that the cerebellum may modulate brain functions altered in drug addiction. We previously demonstrated that cocaine‐induced conditioned preference increased activity at the dorsal posterior ... -
Have we been ignoring the elephant in the room? Seven arguments for considering the cerebellum as part of addiction circuitry
MIQUEL, MARTA; Vázquez Sanromán, Dolores; Carbó Gas, María; Gil-Miravet, Isis; Sanchis-Segura, Carla; Carulli, Daniela; Manzo, Jorge; Coria Ávila, Genaro A. Elsevier (2016)Addiction involves alterations in multiple brain regions that are associated with functions such as memory, motivation and executive control. Indeed, it is now well accepted that addictive drugs produce long-lasting molecular ... -
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
Gil-Miravet, Isis; Mañas-Ojeda, Aroa; Ros Bernal, Francisco; Castillo-Gómez, Esther; Albert Gasco, Hector; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2021-03-18)Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to ... -
Mapping cFos expression after cerebellar and medial prefrontal deactivations in rats trained to acquire cocaine-induced preference conditioning
Gil-Miravet, Isis; Guarque-Chabrera, Julian; Musoles Lleó, Juan Luis; Olucha-Bordonau, Francisco E; MIQUEL, MARTA Mediterranean Neuroscience Society (2017-06) -
Neural correlates of cocaine-induced conditioned place preference in the posterior cerebellar cortex
Rodríguez Borillo, Olga; Roselló-Jiménez, Lorena; Guarque-Chabrera, Julian; Palau-Batet, María; Gil-Miravet, Isis; Pastor Medall, Raúl; MIQUEL, MARTA; Font Hurtado, Laura Frontiers Media (2023)Introduction: Addictive drugs are potent neuropharmacological agents capable of inducing long-lasting changes in learning and memory neurocircuitry. With repeated use, contexts and cues associated with consumption can ... -
Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics
Bathgate, Ross A. D.; Praveen, Praveen; Sethi, Ashish; Dhingra, Rishi R.; Kocan, Martina; Ou, Qinghao; Valkovic, Adam L.,; Gil-Miravet, Isis; Navarro Sánchez, Mónica; Olucha-Bordonau, Francisco E; Gundlach, Andrew Lawrence; Rosengren, K. Johan; Dutschmann, Mathias; Hossain, Mohammed Akhter American Chemical Society (2023-08-20)Peptides and peptidomimetics are attractive drug candidates because of their high target specificity and low-toxicity profiles. Developing peptidomimetics using hydrocarbon (HC)-stapling or other stapling strategies has ... -
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
Gil-Miravet, Isis; Nuñez Molina, Angel; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Ros, Francisco; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Springer (2023)Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in ... -
Papel del prelímbico en la adquisición de la memoria de preferencia hacia estímulos asociados a la cocaína
Gil-Miravet, Isis; Torres Garrido, Zaira; González Hernández, Fernando; Palma Gómez, Araceli; MIQUEL, MARTA Universitat Jaume I (2016)Introducción: Hallazgos previos sugieren que el desarrollo de la adicción a las drogas puede ser entendido en términos de interacción entre los mecanismos cerebrales de memoria pavloviana e instrumental que subyacen a la ... -
Patrones de colateralización de los núcleos del rafe y del núcleo incertus al sistema septo-hipocámpico
Navarro Sánchez, Mónica; Gil-Miravet, Isis; Montero Caballero, Daniel; Lassili, Chaima; Es-Safi, Soukaina; Olucha-Bordonau, Francisco E Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2023)El núcleo incertus (NI), rico en relaxina 3 (rlN3), y los núcleos del rafe, ricos en serotonina (5ht), son unidades modulares de la línea media del tronco cerebral que influyen en diversas funciones cerebrales, entre ... -
Postnatal development of the relaxin-3 innervation of the rat medial septum
ROS, FRANCISCO; Gil-Miravet, Isis; Lucerón Morales, Jorge; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2023)Introduction: The septal area provides a rich innervation to the hippocampus regulating hippocampal excitability to different behavioral states and modulating theta rhythmogenesis. However, little is known about the ... -
Prepulse Inhibition in Cocaine Addiction and Dual Pathologies
Gil-Miravet, Isis; Fuertes-Saiz, Alejandro; Benito, Ana; Almodóvar, Isabel; Ochoa, Enrique; Haro Cortés, Gonzalo MDPI (2021-02)Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating ... -
La proyección de Relaxina-3 sobre centros serotoninérgicos en el cerebro de la rata
Montero Caballero, Daniel; Navarro Sánchez, Mónica; Gil-Miravet, Isis; Olucha-Bordonau, Francisco E Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2023)La modulación de los sistemas cognitivos y emocionales dependen de una serie de conexiones ascendentes entre las que se encuentran las conexiones seroto- ninérgicas (5ht) y también las peptidérgicas. La Relaxina-3 ... -
Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users
O'Higgins, Marcelo; Benito, Ana; Real-López, Matias; Gil-Miravet, Isis; Ochoa, Enrique; Haro Cortés, Gonzalo Wiley (2022)Although multiple studies have shown the role genetics plays in personality disorders and in addictions, few have studied the genetic aspects of their comorbidity. Here, we carried out a cross-sectional study in a sample ...