Listar por autoría "92ed98be-9dd3-45f2-bf3d-d56a19593114"

Mostrando ítems 1-7 de 7

    • closedAccess   Amidation through carbamates 

      Latorre, Antonio; Rodríguez, Santiago; Izquierdo Ferrer, Javier; González, Florenci Elsevier (2009)
      N-Alkyl carbamates of primary amines are easily converted into amides under treatment with Grignard reagents. Consequently, primary amines can be converted into amides in a one-pot reaction through carbamate protection and ...

    • closedAccess   Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain 

      Latorre, Antonio; Schirmeister, Tanja; Kesselring, Jochen; Jung, Sascha; Johé, Patrick; Hellmich, Ute A.; Heilos, Anna; Engels, Bernd; Krauth-Siegel, R. Luise; Dirdjaja, Natalie; Bou Iserte, Lledó; Rodríguez, Santiago; González, Florenci American Chemical Society (2016)
      Dipeptidyl nitroalkenes are potent reversible inhibitors of cysteine proteases. Inhibitor 11 resulted to be the most potent one with Ki values of 0.49 and 0.44 nM against rhodesain and cruzain, respectively. According to ...

    • openAccess   Radical Mechanism in the Elimination of 2-Arylsulfinyl Esters 

      Latorre, Antonio; López Martín, Irakusne; Ramírez, Victoria; Rodríguez, Santiago; Izquierdo Ferrer, Javier; González, Florenci; Vicent Barrera, Cristian American Chemical Society (2012-05)
      The mechanism of the dehydrosulfenylation of 2-arylsulfinyl esters was investigated. The reaction was found to follow a homolytic cleavage mechanism as verified by electrospray ionization tandem mass spectrometry and ...

    • openAccess   Stereoisomerization of α-hydroxy-β-sulfenyl-α,β-dimethyl naphthoquinones controlled by nonbonded sulfur–oxygen interactions 

      Latorre, Antonio; Rodríguez, Santiago; Jain, Amit; González, Florenci; Mata Martínez, Jose A Elsevier (2013-03)
      The anti α-hydroxy-β-sulfenyl-α,β-dimethyl naphthoquinones isomerize in basic media into syn/anti mixtures of isomers, giving the syn isomer as the major product. Conversely, anti α-hydroxy-β-alkoxy-α,β-dimethyl naphthoquinones ...

    • openAccess   Study of the Stereoselectivity of the Nucleophilic Epoxidation of 3-Hydroxy-2- methylene Esters 

      Latorre, Antonio; Sáez Cases, José Antonio; Rodríguez, Santiago; González, Florenci Elsevier (2013-01)
      The diastereoselectivity of the nucleophilic epoxidation of 3-hydroxy-2-methylene esters has been studied. The 3-hydroxy-2-methylene esters were obtained through a Morita–Baylis–Hillman reaction. The resulting epoxyesters ...

    • closedAccess   Synthetic studies on the preparation of alanyl epoxysulfones as cathepsin cysteine protease electrophilic traps 

      Latorre, Antonio; Rodríguez, Santiago; González, Florenci; Florea, Bogdan I.; Overkleeft, Herman S. American Chemical Society (2015-07)
      A Darzens reaction between tert-butoxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted into epoxysulfones by reaction with sodium tert-butoxide. Epoxysulfone 10 and chloroketone ...

    • openAccess   Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes 

      Bou Iserte, Lledó; Latorre, Antonio; Rodríguez, Santiago; González, Florenci (2019)
      Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including a Darzens reaction and treatment with an amine or diamine and then with a reducing agent. Additionally, quinoxalines ...