Listar por autoría "72303f99-5d6e-44df-b621-c7a1ce667e36"
Mostrando ítems 1-10 de 10
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Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes, Eric J.; Randall, Patrick A.; Santerre, Jessica L.; Given, A. B.; Sager, Thomas Nikolaj; Correa, Merce; Salamone, John Elsevier (2010)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Salamone, John; Estrada, Alexavier; Epling, Brian; Hart, Evan E.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis Springer (2014-02)Rationale. Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of ... -
Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
Farrar, Andrew M.; Segovia, Kristen N.; Randall, Patrick A.; Nunes, Eric J.; Collins, Lyndsey E.; Stopper, Colin M.; Port, Russell G.; Hockemeyer, J.; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2010-04)Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover, there is evidence of an interaction ... -
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors
Nunes, Eric J.; Randall, Patrick A.; Podurgiel, Samantha J.; Correa, Merce; Salamone, John Elsevier (2013)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions or antagonism leave aspects of appetite ... -
Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142
Sink, Kelly S.; Segovia, Kristen N.; Sink, J.; Randall, Patrick A.; Collins, Lyndsey E.; Correa, Merce; Markus, E. J.; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Salamone, John Elsevier (2010)Cannabinoid CB1 inverse agonists suppress food-motivated behaviors, but may also induce psychiatric effects such as depression and anxiety. To evaluate behaviors potentially related to anxiety, the present experiments ... -
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond
Salamone, John; Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Pardo Andrés, Marta Wiley (2012-01)For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ... -
The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions
Santerre, Jessica L.; Nunes, Eric J.; Kovner, Rotem; Leser, Chelsea E.; Randall, Patrick A.; Collins, Lyndsey E.; López Cruz, Laura; Correa, Merce; Baqi, Younis; Müller, Christa E.; Salamone, John Elsevier (2012)Adenosine A2A and dopamine D2 receptors interact to regulate diverse aspects of ventral and dorsal striatal functions related to motivational and motor processes, and it has been suggested that adenosine A2A antagonists ... -
The VMAT-2 Inhibitor Tetrabenazine Affects EffortRelated Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall, Patrick A.; Lee, Christie A.; Nunes, Eric J.; Yohn, Samantha E.; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2014)Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression ... -
The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion
Yohn, Samantha E.; Thompson, Christian; Randall, Patrick A.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis; Correa, Merce; Salamone, John Springer Verlag (2015)Rationale Depressed people show effort-related motivational symptoms, such as anergia, retardation, lassitude, and fatigue. Animal tests can model these motivational symptoms, and the present studies characterized the ...