• openAccess   A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions 

      Kouhnavardi, Shima; Ecevitoglu, Alev; Dragačević, Vladimir; Sanna, Fabrizio; Arias-Sandoval, Edgar; Kalaba, Predrag; Kirchhofer, Michael; Lubec, Jana; Niello, Marco; Holy, Marion; Zehl, Martin; Pillwein, Matthias; Wackerlig, Judith; Murau, Rita; Mohrmann, Andrea; Beard, Kathryn R.; Sitte, Harald; Urban, Ernst; Sagheddu, Claudia; Pistis, Marco; Plasenzotti, Roberto; Salamone, John; Langer, Thierry; Lubec, Gert; Monje, Francisco J. MDPI (2022-07)
      Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning ...
    • openAccess   Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat 

      Lubec, Jana; Hussein, Ahmed M.; Kalaba, Predrag; Feyissa, Daniel Daba; Arias-Sandoval, Edgar; Cybulska-Klosowicz, Anita; Bezu, Mekite; Stojanovic, Tamara; Korz, Volker; Malikovic, Jovana; Aher, Nilima Y.; Zehl, Martin; Dragačević, Vladimir; Leban, Johann Jakob; Sagheddu, Claudia; Wackerlig, Judith; Pistis, Marco; Correa, Merce; Langer, Thierry; Urban, Ernst; Höger, Harald; Lubec, Gert MDPI (2023-03)
      The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent a major step forward, current ...