Listar por autoría "599bf2fc-3349-4566-94ad-5c1751fbf9f0"

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    • openAccess   Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis 

      Angelastro, Antonio; Ruiz-Pernía, José Javier; Tuñón, Iñaki; Moliner, Vicent; Luk, Louis Y. P.; Allemann, Rudolf K. American Chemical Society (2019-09-23)
      Hydride transfer is widespread in nature and has an essential role in applied research. However, the mechanisms of how this transformation occurs in living organisms remain a matter of vigorous debate. Here, we examined ...

    • openAccess   Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host 

      Nödling, Alexander; Świderek, Katarzyna; Castillo, Raquel; Hall, Jonathan W.; Angelastro, Antonio; Morrill, Louis; Tsai, Yu-Hsuan; Moliner, Vicent; Luk, Louis Y. P. Wiley (2018-09-17)
      There has been growing interest in performing organocatalysis within a supramolecular system as a means of controlling reaction reactivity and stereoselectivity. Here, a protein is used as a host for iminium catalysis. A ...