Listar por autoría "3ce6d764-fb83-4a4a-a5b6-0fa39dec1a7b"
Mostrando ítems 1-5 de 5
-
A computational study of the phosphoryl transfer reaction between ATP and Dha in Aqueous Solution
Bordes, Isabel; Ruiz-Pernía, José Javier; Castillo, Raquel; Moliner, Vicent Royal Society of Chemistry (2015)Phosphoryl transfer reactions are ubiquitous in biology, being involved in processes ranging from energy and signal transduction to the replication genetic material. Dihydroxyacetone phosphate (Dha-P), an intermediate ... -
Computational Study of the Phosphoryl Donor Activity of Dihydroxyacetone Kinase from ATP to Inorganic Polyphosphate
Bordes, Isabel; García-Junceda, Eduardo; Sánchez Moreno, Israel; Castillo, Raquel; Moliner, Vicent Wiley (2017-10)Adenosine triphosphate (ATP) is the main biological phosphoryl donor required in many enzymes including dihydroxyacetone kinases (DHAKs) that convert dihydroxyacetone (Dha) into dihydroxyacetone phosphate (Dha-P), a key ... -
Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?
Bordes, Isabel; Recatalá, José; Świderek, Katarzyna; Moliner, Vicent MDPI (2015)Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic ... -
Theoretical Study of the Phosphoryl Transfer Reaction from ATP to Dha Catalyzed by DhaK from Escherichia coli
Bordes, Isabel; Castillo, Raquel; Moliner, Vicent American Chemical Society (2017-09)Protein kinases, representing one of the largest protein families involved in almost all aspects of cell life, have become one of the most important targets for the development of new drugs to be used in, for instance, ... -
Tuning the Phosphoryl Donor Specificity of Dihydroxyacetone Kinase from ATP to Inorganic Polyphosphate. An Insight from Computational Studies
Sánchez Moreno, Israel; Bordes, Isabel; Castillo, Raquel; Ruiz-Pernía, José Javier; Moliner, Vicent; García Junceda, Eduardo MDPI (2015-11-24)Dihydroxyacetone (DHA) kinase from Citrobacter freundii provides an easy entry for the preparation of DHA phosphate; a very important C3 building block in nature. To modify the phosphoryl donor specificity of this enzyme ...