Listar por autoría "2c044c35-6b77-41b9-8930-e4c84f368c1c"
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Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acid
Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Springer (2012)Rationale Hydrogen peroxide (H2 O2) is the co-substrate used by catalase to metabolize ethanol to acetaldehyde in the brain. This centrally formed acetaldehyde has been involved in several ethanol-related behaviors. ... -
Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice
Roger Sánchez, C.; Aguilar, M.A.; Rodriguez-Arias, Marta; González Aragón, Carlos Manuel; Miñarro, Josse Elsevier (2012)Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, ... -
Alpha-lipoic acid, a scavenging agent for H2O2, reduces ethanol-stimulated locomotion in mice
Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Springer-Verlag (2011-07-19)Rationale The main system of central ethanol oxidation is mediated by the enzyme catalase. By reacting with H2O2, brain catalase forms compound I (the catalase–H2O2 system), which is able to oxidize ethanol to acetaldehyde ... -
Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
Escrig, Miguel A.; Pardo Andrés, Marta; González Aragón, Carlos Manuel; Correa, Merce Elsevier (2012)Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of ... -
Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation
Tarragon Cros, Ernesto; Baliño, Pablo; González Aragón, Carlos Manuel Elsevier (2014)Centrally formed acetaldehyde has proven to be responsible for several psychopharmacological effects induced by ethanol. In addition, it has been suggested that the cAMP-PKA signaling transduction pathway plays an important ... -
Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2
Pascual, María; Baliño, Pablo; González Aragón, Carlos Manuel; Guerri, Consuelo Springer (2015)Recent evidence supports the influence of neuroimmune system activation on behavior. We have demonstrated that ethanol activates the innate immune system by stimulating toll-like receptor 4 (TLR4) signaling in glial cells, ... -
Dantrolene blockade of ryanodine receptor impairs ethanol-induced behavioral stimulation, ethanol intake and loss of righting reflex
Tarragon Cros, Ernesto; Baliño, Pablo; González Aragón, Carlos Manuel Elsevier (2012-08)Calcium has been characterized as one of the most ubiquitous, universal and versatile intracellular signals. Among other substances with the ability to alter intracellular calcium levels, ethanol has been described as ... -
Effects of Acute Ethanol Administration on Brain Oxidative Status: The Role of Acetaldehyde
Baliño, Pablo; Romero Cano, Ricard; Sanchez-Andres, Juan V.; Valls, Victoria; González Aragón, Carlos Manuel; Muriach, Maria Wiley (2019-08)Background: Ethanol (EtOH), one of the most widely consumed substances of abuse, can induce brain damage and neurodegeneration. EtOH is centrally metabolized into acetaldehyde, which has been shown to be responsible for ... -
Ethanol drinking-in-the-dark facilitates behavioral sensitization to ethanol in C57BL/6J, BALB/cByJ, but not in mu-opioid receptor deficient CXBK mice
Tarragon Cros, Ernesto; Baliño, Pablo; González Aragón, Carlos Manuel; Pastor Medall, Raúl Elsevier (2012)Background: Neuroplasticity associated with drug-induced behavioral sensitization has been associated with excessive drug pursuit and consumption characteristic of addiction. Repeated intraperitoneal (ip) injections of ... -
Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage
Pascual, María; Baliño, Pablo; Alfonso Loeches, Silvia; González Aragón, Carlos Manuel; Guerri, Consuelo Elsevier (2011-06-01)Toll-like receptors (TLRs) play an important role in the innate immune response, and emerging evidence indicates their role in brain injury and neurodegeneration. Our recent results have demonstrated that ethanol is capable ... -
In Vivo Study of Ethanol-Activated Brain Protein Kinase A: Manipulations of Ca2+ Distribution and Flux
Baliño, Pablo; Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Wiley (2014-03)Background The cAMP-dependent protein kinase (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol (EtOH)-induced behavioral actions. In vivo, short-term ... -
Induction of brain cytochrome P450 2E1 boosts the locomotor-stimulating effects of ethanol in mice
Ledesma Llorente, Juan Carlos; MIQUEL, MARTA; Pascual, María; Guerri, Consuelo; González Aragón, Carlos Manuel Elsevier (2014)In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of EtOH-derived acetaldehyde, whereas cerebral cytochrome P450 2E1 ... -
Intracellular calcium chelation with BAPTA-AM modulates ethanol-induced behavioral effects in mice
Baliño, Pablo; Monferrer Sales, Lidón; Pastor Medall, Raúl; González Aragón, Carlos Manuel Elsevier (2012)Calcium (Ca2+) has been characterized as one of the most ubiquitous, universal and versatile intracellular signaling molecules responsible for controlling numerous cellular processes. Ethanol-induced effects on Ca2+ ... -
Involvement of brain catalase activity in the acquisition of ethanol-induced conditioned place preference
Font Hurtado, Laura; MIQUEL, MARTA; González Aragón, Carlos Manuel Elsevier (2008)It has been suggested that some of the behavioral effects produced by ethanol are mediated by its first metabolite, acetaldehyde. The present research addressed the hypothesis that catalase-dependent metabolism of ethanol ... -
Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in mice
Pastor Medall, Raúl; Font Hurtado, Laura; MIQUEL, MARTA; Phillips, Tamara J.; González Aragón, Carlos Manuel Wiley (2011-10-20)Background: Increasing evidence indicates that mu- and delta-opioid receptors are decisively involved in the retrieval of memories underlying conditioned effects of ethanol. The precise mechanism by which these receptors ... -
Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials
Ledesma Llorente, Juan Carlos; Font Hurtado, Laura; Baliño, Pablo; González Aragón, Carlos Manuel Springer (2013)Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, modulate ... -
Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: Effects of diltiazem and verapamil
Baliño, Pablo; Pastor Medall, Raúl; González Aragón, Carlos Manuel Elsevier (2010-06)Calcium flux through voltage gate calcium channels (VGCC) is involved in many neuronal processes such as membrane depolarization, gene expression, hormone secretion, and neurotransmitter release. Several studies have shown ... -
Reduction in Central H2O2 Levels Prevents Voluntary Ethanol Intake in Mice: A Role for the Brain Catalase- H2O2 System in Alcohol Binge Drinking
Ledesma Llorente, Juan Carlos; Baliño, Pablo; González Aragón, Carlos Manuel Wiley (2014-01)Background: Hydrogen peroxide (H2O2) is the cosubstrate used by the enzyme catalase to form Compound I (the catalase-H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the ... -
Role of CA2+/calmodulin on ethanol neurobehavioral effects
González Aragón, Carlos Manuel; Ledesma Llorente, Juan Carlos; Baliño, Pablo Springer (2014-05)Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated ... -
Role of phosphodiesterase-4 on ethanol elicited locomotion and narcosis
Baliño, Pablo; Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Elsevier (2016)The cAMP signaling pathway has emerged as an important modulator of the pharmacological effects of ethanol. In this respect, the cAMP-dependent protein kinase has been shown to play an important role in the modulation of ...