Listar por autoría "0710ffd6-ff4b-435f-b1bc-51d9397085b8"

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    • openAccess   Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host 

      Nödling, Alexander; Świderek, Katarzyna; Castillo, Raquel; Hall, Jonathan W.; Angelastro, Antonio; Morrill, Louis; Tsai, Yu-Hsuan; Moliner, Vicent; Luk, Louis Y. P. Wiley (2018-09-17)
      There has been growing interest in performing organocatalysis within a supramolecular system as a means of controlling reaction reactivity and stereoselectivity. Here, a protein is used as a host for iminium catalysis. A ...

    • openAccess   The role of streptavidin and its variants in catalysis by biotinylated secondary amines 

      Nödling, Alexander; Santi, Nicolò; Castillo, Raquel; Lipka-Lloyd, Magdalena; Jin, Yi; Morrill, Louis; Świderek, Katarzyna; Moliner, Vicent; Luk, Louis Yu Pan Royal Society of Chemistry (2021-11-15)
      Here, we combine the use of host screening, protein crystallography and QM/MM molecular dynamics simulations to investigate how the protein structure affects iminium catalysis by biotinylated secondary amines in a model ...