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dc.contributorPastor Medall, Raúl
dc.contributorUniversitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia
dc.contributor.authorCamarena Delgado, María del Carmen
dc.date.accessioned2014-07-29T11:41:06Z
dc.date.available2014-07-29T11:41:06Z
dc.date.issued2014-07-23
dc.identifier.urihttp://hdl.handle.net/10234/98645
dc.descriptionTreball Final de Grau en Psicologia. Codi: PS1048. Curs 2013-2014ca_CA
dc.description.abstractIt has been proposed that neuroadaptations underlying psychomotor sensitization induced by repeated administration of drugs of abuse are associated with pathological, excessive motivation toward drugs and drug-associated stimuli, and are involved in facilitation and maintenance of addictive behavior. It has been shown that cocaine-induced psychomotor sensitization is sensitive to the effects of conditioning; expression of sensitization appears to be dependent on the context in which it was acquired. In this regard, it has been proposed that cues associated with repeated administration of drugs can trigger motivational states that can in turn facilitate drug seeking and intake. Therefore, conditional effects are important to study in the context of drug addiction. Research focusing on consolidation and expression of memories supporting cueinduced behaviors, is currently paying considerable attention to the noradrenergic (NE) system, and in particular to α₁ and β-adrenergic receptors. First, our studies in the laboratory focused on exploring the effects of propranolol (nonspecific antagonist of b-adrenergic receptors), with prior repeated administration of cocaine / saline (inducing conditioned sensitization) in the same context (CS +). Sensitized animals showed further drug-free, context-dependent hiperactivation, an effect that was prevented by propranolol. The present study further explored the role of NE receptors by using prazosin, a selective α-adrenergic receptors antagonist. Male DBA/2J animals received intraperitoneal injections of 0 or 20 mg/kg of cocaine on alternate days (Mon, Wed, Fri, Mon, Wed, Fri) in order to achieve psychomotor sensitization. Locomotor activity of animals treated with cocaine was always assessed in a chamber with a particular flooring configuration (grid or hole; counterbalanced), CS+. This design was also used for saline treated animals (CS-). On day 15 of the experiment all animals were presented with the CS +; we obtained conditioned hyperactivity in the group previously treated with cocaine. Prazosin did not block this effect. The finals results were that prazosin has no effect on repeated administration of cocaine-induced conditioned hyperactivity.ca_CA
dc.format.extent52 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isospaca_CA
dc.publisherUniversitat Jaume Ica_CA
dc.subjectGrau en Psicologiaca_CA
dc.subjectGrado en Psicologíaca_CA
dc.subjectBachelor's Degree in Psychologyca_CA
dc.subjectcocaineca_CA
dc.subjectsensitizationca_CA
dc.subjectdrug addictionca_CA
dc.subjectconditioned hyperactivityca_CA
dc.subjectNE systemca_CA
dc.subjectα₁-Adrenergic receptorca_CA
dc.subjectβ- Adrenergic receptor and Prazosinca_CA
dc.titleParticpación del sistema NE en la expresión de memorias condicionadas asociadas a la administración de cocaínaca_CA
dc.typeinfo:eu-repo/semantics/bachelorThesisca_CA
dc.educationLevelEstudios de Gradoca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA


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