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dc.contributor.authorFerrer Tasies, Lidia
dc.contributor.authorMoreno Calvo, Evelyn
dc.contributor.authorCano Sarabia, Mary
dc.contributor.authorAguilella-Arzo, Marcel
dc.contributor.authorAngelova, Angelina
dc.contributor.authorLesieur, Sylviane
dc.contributor.authorRicart, Susagna
dc.contributor.authorFaraudo, Jordi
dc.contributor.authorVentosa, Nora
dc.contributor.authorVeciana, Jaume
dc.identifier.citationFERRER-TASIES, Lidia, et al. Quatsomes: Vesicles formed by self-assembly of sterols and quaternary ammonium surfactants. Langmuir, 2013, vol. 29, no 22, p. 6519-6528.ca_CA
dc.description.abstractThermodynamically stable nanovesicle structures are of high interest for academia and industry in a wide variety of application fields, ranging from preparation of nanomaterials to nanomedicine. Here, we show the ability of quaternary ammonium surfactants and sterols to self-assemble, forming stable amphiphilic bimolecular building-blocks with the appropriate structural characteristics to form in aqueous phases, closed bilayers, named quatsomes, with outstanding stability, with time and temperature. The molecular self-assembling of cholesterol and surfactant cetyltrimethylammonium bromide (CTAB) was studied by quasi-elastic light scattering, cryogenic transmission electron microscopy, turbidity (optical density) measurements, and molecular dynamic simulations with atomistic detail, upon varying the cholesterol-to- surfactant molar ratio. As pure species, CTAB forms micelles and insoluble cholesterol forms crystals in water. However, our molecular dynamic simulations reveal that the synergy between CTAB and cholesterol molecules makes them self-assemble into bimolecular amphiphiles and then into bilayers in the presence of water. These bilayers have the same structure of those formed by double-tailed unimolecular amphiphilesca_CA
dc.description.sponsorShipThis work was supported by grants from DGI, Spain, projects POMAS (CTQ2010-019501), CONSOLIDER-NANOSELECT- CSD2007-00041, FIS2009-13370-C02-02, FIS2010-19810, and to DGR, Catalunya (project 2005SGR00591 and 2009SGR0164). We acknowledge financial support from the Instituto de Salud Carlos III, through “Acciones CIBER”. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions, and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors appreciate the financial support through the project “Development of nanomedicines for enzymatic replacement therapy in Fabry disease” granted by the Fundació MaratóTV3. E. Moreno-Calvo acknowledges the MICINN for a Juan de la Cierva postdoctoral contract. L.F.-T. thanks the MICINN for her FPI bursary. N.V. thanks Banco de Santander for the chair of Knowledge and Technology Transfer Parc de Recerca UAB-Santander. We also thank TECNIO network for financial support on technological transfer activities related to this work. We also thank the UAB Microscopy service for their help in recording cryo-TEM, TEM, and optical microscopy images. The authors thank the suggestions of Prof. Feral Temelli about the use of sterol components for developing quatsomes.ca_CA
dc.format.extent9 p.ca_CA
dc.publisherAmerican Chemical Societyca_CA
dc.relation.isPartOfLangmuir (2013) vol. 29, no 22ca_CA
dc.rightsCopyright © American Chemical Societyca_CA
dc.subjectCationic surfactantsca_CA
dc.subjectDrug nanocarriersca_CA
dc.titleQuatsomes: Vesicles Formed by Self-Assembly of Sterols and Quaternary Ammonium Surfactantsca_CA

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