Quatsomes: Vesicles Formed by Self-Assembly of Sterols and Quaternary Ammonium Surfactants
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Otros documentos de la autoría: Ferrer Tasies, Lidia; Moreno Calvo, Evelyn; Cano Sarabia, Mary; Aguilella-Arzo, Marcel; Angelova, Angelina; Lesieur, Sylviane; Ricart, Susagna; Faraudo, Jordi; Ventosa, Nora; Veciana, Jaume
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http://dx.doi.org/10.1021/la4003803 |
Metadatos
Título
Quatsomes: Vesicles Formed by Self-Assembly of Sterols and Quaternary Ammonium SurfactantsAutoría
Fecha de publicación
2013Editor
American Chemical SocietyISSN
0743-7463; 1520-5827Cita bibliográfica
FERRER-TASIES, Lidia, et al. Quatsomes: Vesicles formed by self-assembly of sterols and quaternary ammonium surfactants. Langmuir, 2013, vol. 29, no 22, p. 6519-6528.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.acs.org/doi/abs/10.1021/la4003803Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Thermodynamically stable nanovesicle structures are of high interest for academia and industry in a wide variety of application fields, ranging from preparation of nanomaterials to nanomedicine. Here, we show the ... [+]
Thermodynamically stable nanovesicle structures are of high interest for academia and industry in a wide variety of application fields, ranging from preparation of nanomaterials to nanomedicine. Here, we show the ability of quaternary ammonium surfactants and sterols to self-assemble, forming stable amphiphilic bimolecular building-blocks with the appropriate structural characteristics to form in aqueous phases, closed bilayers, named quatsomes, with outstanding stability, with time and temperature. The molecular self-assembling of cholesterol and surfactant cetyltrimethylammonium bromide (CTAB) was studied by quasi-elastic light scattering, cryogenic transmission electron microscopy, turbidity (optical density) measurements, and molecular dynamic simulations with atomistic detail, upon varying the cholesterol-to- surfactant molar ratio. As pure species, CTAB forms micelles and insoluble cholesterol forms crystals in water. However, our molecular dynamic simulations reveal that the synergy between CTAB and cholesterol molecules makes them self-assemble into bimolecular amphiphiles and then into bilayers in the presence of water. These bilayers have the same structure of those formed by double-tailed unimolecular amphiphiles [-]
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Langmuir (2013) vol. 29, no 22Derechos de acceso
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