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dc.contributor.authorHernández Escolano, Miriam
dc.contributor.authorJuan Díaz, M.
dc.contributor.authorMartínez Ibáñez, M.
dc.contributor.authorSuay Antón, Julio José
dc.contributor.authorGoñi, Isabel
dc.contributor.authorGURRUCHAGA, MARILO
dc.identifier.citationHERNÁNDEZ ESCOLANO, M., et al. Synthesis of hybrid sol–gel materials and their biological evaluation with human mesenchymal stem cells. Journal of Materials Science: Materials in Medicine, 2013, 24.6: 1491-1499.ca_CA
dc.description.abstractSurface engineering of biomaterials could promote the osseointegration of implants. In this work, two types of hybrid sol–gel materials were developed to stimulate cell attachment, proliferation and differentiation of osteogenic cells. One type was synthesised from vinyl triethoxysilane (VTES) and tetraethyl-orthosilicate (TEOS) at different molar ratios, while the other from VTES and hydroxyapatite particles (HAp). Hybrid materials were systematically investigated using nuclear magnetic resonance, Fourier transform infrared spectroscopy and contact angle metrology. The biocompatibility and osseoinduction of the coatings were evaluated by measuring mesenchymal stem cell proliferation using MTT assays and analysing the mineralised extracellular matrix production by quantifying calcium-rich deposits. The results highlighted the versatility of these coatings in obtaining different properties by changing the molar ratio of the VTES:TEOS precursors. Thus, mineralisation was stimulated by increasing TEOS content, while the addition of HAp improved cell proliferation but worsened mineralisation.ca_CA
dc.format.extent8 p.ca_CA
dc.relation.isPartOfJournal of Materials Science: Materials in Medicine June 2013, Volume 24, Issue 6ca_CA
dc.rights© Springer Science+Business Media New York 2013ca_CA
dc.subjectBiological evaluationca_CA
dc.subjectExtracellular matrix productionca_CA
dc.subjectHuman mesenchymal stem cellsca_CA
dc.subjectHybrid sol-gel materialsca_CA
dc.subjectHydroxyapatite particlesca_CA
dc.subjectOsteogenic cellsca_CA
dc.subjectSurface engineeringca_CA
dc.titleSynthesis of hybrid sol-gel materials and their biological evaluation with human mesenchymal stem cellsca_CA

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