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dc.contributor.authorLópez Cruz, Laura
dc.contributor.authorSalamone, John D.
dc.contributor.authorCorrea Sanz, Mercè
dc.identifier.citationLÓPEZ-CRUZ, Laura; SALAMONE, John D.; CORREA, Mercè. The Impact of Caffeine on the Behavioral Effects of Ethanol Related to Abuse and Addiction: A Review of Animal Studies. Journal of Caffeine Research, 2013, 3.1: 9-21.ca_CA
dc.description.abstractThe impact of caffeine on the behavioral effects of ethanol, including ethanol consumption and abuse, has become a topic of great interest due to the rise in popularity of the so-called energy drinks. Energy drinks high in caffeine are frequently taken in combination with ethanol under the popular belief that caffeine can offset some of the intoxicating effects of ethanol. However, scientific research has not universally supported the idea that caffeine can reduce the effects of ethanol in humans or in rodents, and the mechanisms mediating the caffeine–ethanol interactions are not well understood. Caffeine and ethanol have a common biological substrate; both act on neuro- chemical processes related to the neuromodulator adenosine. Caffeine acts as a nonselective adenosine A1 and A2A receptor antagonist, while ethanol has been demonstrated to increase the basal adenosinergic tone via mul- tiple mechanisms. Since adenosine transmission modulates multiple behavioral processes, the interaction of both drugs can regulate a wide range of effects related to alcohol consumption and the development of ethanol addic- tion. In the present review, we discuss the relatively small number of animal studies that have assessed the inter- actions between caffeine and ethanol, as well as the interactions between ethanol and subtype-selective adenosine receptor antagonists, to understand the basic findings and determine the possible mechanisms of action under- lying the caffeine–ethanol interactions.ca_CA
dc.format.extent13 p.ca_CA
dc.publisherMary Ann Liebert, Inc. publishersca_CA
dc.relation.isPartOfJourna of Caffeine Research, 2013, 3.1: 9-21ca_CA
dc.rights©2013 Mary Ann Liebert, Inc. Publishers.ca_CA
dc.subjectcaffeine–ethanol interactionsca_CA
dc.titleThe Impact of Caffeine on the Behavioral Effects of Ethanol Related to Abuse and Addiction: A Review of Animal Studiesca_CA

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