Regional Brain Atrophy and Functional Connectivity Changes Related to Fatigue in Multiple Sclerosis
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Otros documentos de la autoría: Cruz Gómez, Álvaro Javier; Ventura Campos, Mercedes; Belenguer Benavides, Antonio; Avila, Cesar; Forn, Cristina
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Título
Regional Brain Atrophy and Functional Connectivity Changes Related to Fatigue in Multiple SclerosisAutoría
Fecha de publicación
2013Editor
Public Library of ScienceISSN
1932-6203Cita bibliográfica
Cruz Gómez ÁJ, Ventura Campos N, Belenguer A, Ávila C, Forn C (2013) Regional Brain Atrophy and Functional Connectivity Changes Related to Fatigue in Multiple Sclerosis. PLoS ONE 8(10): e77914. doi:10.1371/journal.pone.0077914Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Fatigue is one of the most frequent symptoms in multiple sclerosis (MS), and recent studies have described a
relationship between the sensorimotor cortex and its afferent and efferent pathways as a substrate of ... [+]
Fatigue is one of the most frequent symptoms in multiple sclerosis (MS), and recent studies have described a
relationship between the sensorimotor cortex and its afferent and efferent pathways as a substrate of fatigue. The
objectives of this study were to assess the neural correlates of fatigue in MS through gray matter (GM) and white
matter (WM) atrophy, and resting state functional connectivity (rs-FC) of the sensorimotor network (SMN). Eighteen
healthy controls (HCs) and 60 relapsing-remitting patients were assessed with the Fatigue Severity Scale (FSS).
Patients were classified as fatigued (F) or nonfatigued (NF). We investigated GM and WM atrophy using voxel-based
morphometry, and rs-FC changes with a seed-based method and independent component analysis (ICA). F patients
showed extended GM and WM atrophy focused on areas related to the SMN. High FSS scores were associated with
reductions of WM in the supplementary motor area. Seed analysis of GM atrophy in the SMN showed that HCs
presented increased rs-FC between the primary motor and somatosensory cortices while patients with high FSS
scores were associated with decreased rs-FC between the supplementary motor area and associative
somatosensory cortex. ICA results showed that NF patients presented higher rs-FC in the primary motor cortex
compared to HCs and in the premotor cortex compared to F patients. Atrophy reduced functional connectivity in SMN
pathways and MS patients consequently experienced high levels of fatigue. On the contrary, NF patients experienced
high synchron [-]
Publicado en
PLoS ONE, 2013, Volume 8, Issue 10, e77914Derechos de acceso
info:eu-repo/semantics/openAccess
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- PSB_Articles [1294]
- EDU_Altres [8]
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permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited