Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human.
Scholar | Other documents of the author: Fagundo, Ana B.; De la Torre, Rafael; Jiménez-Murcia, Susana; Agüera, Zaida; Pastor, Antoni; Casanueva, Felipe F.; Granero, Roser; Baños, Rosa; Botella, Cristina; Pino Gutiérrez, Amparo del; Fernández-Real, José Manuel; Fernández García, José Carlos; Frühbeck, Gema; Gómez Ambrosi, Javier; Menchón, José Manuel; Moragrega Vergara, Inés; Rodríguez, Roser; Tárrega, Salomé; Tinahones Madueño, Francisco Javier; Fernández Aranda, Fernando
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TitleModulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human.
Publisher versionhttp://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...
PublisherPublic Library of Science
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrah ... [+]
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches. [-]
Bibliographic citationFagundo AB, de la Torre R, Jiménez-Murcia S, Agüera Z, Pastor A, et al. (2013) Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. PLoS ONE 8(6): e66387. doi:10.1371/journal.pone.0066387
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Except where otherwise noted, this item's license is described as Copyright: 2013 Fagundo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.