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dc.contributor.authorBarcia, Carlos
dc.contributor.authorRos Gómez, Carmen María
dc.contributor.authorAnnese, Valentina
dc.contributor.authorCarrillo-de Sauvage, María Ángeles
dc.contributor.authorRos Bernal, Francisco
dc.contributor.authorGómez, Aurora
dc.contributor.authorYuste Jiménez, José Enrique
dc.contributor.authorCampuzano Brando, Carmen María
dc.contributor.authorDe Pablos, Vicente
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.date.accessioned2013-09-25T13:50:19Z
dc.date.available2013-09-25T13:50:19Z
dc.date.issued2012
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10234/73234
dc.description.abstractThe role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental mouse model of Parkinson’s disease following the intraperitoneal injection of MPTP. The specific intoxication of dopaminergic neurons induces the cellular polarization of microglia, leading to the formation of body-to-body neuron-glia contacts, called gliapses, which precede neuron elimination. Inhibiting ROCK/Cdc42-mediated microglial motility in vivo blocks the activating features of microglia, such as increased cell size and number of filopodia and diminishes their phagocyting/secreting domains, as the reduction of the Golgi apparatus and the number of microglia-neuron contacts has shown. High-resolution confocal images and three-dimensional rendering demonstrate that microglia engulf entire neurons at one-to-one ratio, and the microglial cell body participates in the formation of the phagocytic cup, engulfing and eliminating neurons in areas of dopaminergic degeneration in adult mammals.ca_CA
dc.format.extent13 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherNature Publishing Groupca_CA
dc.relation.isPartOfScientific Reports, 2012, Vol. 2, Num. 809ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectInflammationca_CA
dc.subjectCellular imagingca_CA
dc.subjectCell death in the nervous systemca_CA
dc.subjectParkinson’s diseaseca_CA
dc.titleROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivoca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1038/srep00809
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.readcube.com/articles/10.1038/srep00809?locale=enca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


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