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dc.contributor.authorVerdiá Báguena, Carmen
dc.contributor.authorQueralt-Martín, María
dc.contributor.authorAguilella, Vicente
dc.contributor.authorAlcaraz, Antonio
dc.date.accessioned2013-06-25T07:47:25Z
dc.date.available2013-06-25T07:47:25Z
dc.date.issued2012
dc.identifier.issn1932-7447
dc.identifier.urihttp://hdl.handle.net/10234/68021
dc.description.abstractThe quest for innovative tunable nanodevices has mainly focused on switches that modulate their properties through engineered conformational changes. We propose here an alternative route that takes advantage of the crucial role that trace elements play in biological nanosystems. To this end, the effect of lanthanum, a high-valence rare-earth metal, known as blocker and modulator of many ion channels, has been studied in a wide, weakly selective biological pore, the bacterial porin outer membrane protein F (OmpF). We show that millimolar concentrations of lanthanum chloride have a dramatic impact on OmpF, reducing the conductance for positive but not for negative applied voltages, thus inducing switchable, reversible ion current rectification. By applying an external wave to this lanthanum-induced diode, we show that the system can consistently perform like a wave rectifier at considerably higher frequencies than previous nanofluidic diodes. This finding may be the starting point to develop molecular ratchets suitable for a variety of engineering applications.ca_CA
dc.language.isoengca_CA
dc.publisherAmerican Chemical Societyca_CA
dc.relation.isPartOfThe Journal of Physical Chemistry C, 116, 39ca_CA
dc.rightsCopyright © 2012 American Chemical Societyca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectBiological membranes;ca_CA
dc.subjectChlorine compoundsca_CA
dc.subjectLanthanumca_CA
dc.subjectNanosystemsca_CA
dc.subjectProteinsca_CA
dc.titleProtein Ion Channels as Molecular Ratchets. Switchable Current Modulation in Outer Membrane Protein F Porin Induced by Millimolar La3+ Ionsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1021/jp210790r
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://pubs.acs.org/doi/abs/10.1021/jp210790rca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


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