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Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference
dc.contributor.author | Font Hurtado, Laura | |
dc.contributor.author | Cunningham, Christopher L. | |
dc.date.accessioned | 2013-05-23T14:54:22Z | |
dc.date.available | 2013-05-23T14:54:22Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://hdl.handle.net/10234/64233 | |
dc.description.abstract | The reconsolidation hypothesis posits that established emotional memories, when reactivated, become labile and susceptible to disruption. Post-retrieval injection of propranolol (PRO), a nonspecific ß-adrenergic receptor antagonist, impairs subsequent retention performance of a cocaine- and a morphine-induced conditioned place preference (CPP), implicating the noradrenergic system in the reconsolidation processes of drug-seeking behavior. An important question is whether post-retrieval PRO disrupts memory for the drug-cue associations, or instead interferes with extinction. In the present study, we evaluated the role of the ß-adrenergic system on the reconsolidation and extinction of ethanol-induced CPP. Male DBA/2J mice were trained using a weak or a strong conditioning procedure, achieved by varying the ethanol conditioning dose (1 or 2 g/kg) and the number of ethanol trials (2 or 4). After acquisition of ethanol CPP, animals were given a single post-retrieval injection of PRO (0, 10 or 30 mg/kg) and tested for memory reconsolidation 24 h later. Also, after the first reconsolidation test, mice received 18 additional 15-min choice extinction tests in which PRO was injected immediately after every test. Contrary to the prediction of the reconsolidation hypothesis, a single PRO injection after the retrieval test did not modify subsequent memory retention. In addition, repeated post-retrieval administration of PRO did not interfere with extinction of CPP in mice. Overall, our data suggest that the ß-adrenergic receptor does not modulate the associative processes underlying ethanol CPP. | ca_CA |
dc.format.extent | 36 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Pharmacology Biochemistry and Behavior, Volume 101, Issue 2, April 2012 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Extinction | ca_CA |
dc.subject | Reconsolidation | ca_CA |
dc.subject | Conditioned Place Preference | ca_CA |
dc.subject | Propranolol | ca_CA |
dc.subject | Alcohol | ca_CA |
dc.subject | Mice | ca_CA |
dc.title | Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.pbb.2012.01.009 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://ac.els-cdn.com/S009130571200010X/1-s2.0-S009130571200010X-main.pdf?_tid=d301132c-c3b7-11e2-8580-00000aab0f6b&acdnat=1369320686_09cb90c7b8c65abd63534b3b88e4c04b | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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