Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
Impacte
Scholar |
Altres documents de l'autoria: Marco, J. Alberto; García Pla, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara; Notararigo, Sara; Díaz, J. Fernando; Barasoain, Isabel
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONAquest recurs és restringit
http://dx.doi.org/10.1016/j.ejmech.2011.02.011 |
Metadades
Títol
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubulesAutoria
Data de publicació
2011-05Editor
ElsevierTipus de document
info:eu-repo/semantics/articleParaules clau / Matèries
Resum
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active ... [+]
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities [-]
Publicat a
European Journal of Medicinal ChemistryDrets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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