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Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task
dc.contributor.author | Bustamante, Juan Carlos | |
dc.contributor.author | Barrós-Loscertales, Alfonso | |
dc.contributor.author | Ventura Campos, Mercedes | |
dc.contributor.author | Sanjuán Tomás, Ana | |
dc.contributor.author | Llopis Llácer, Juan José | |
dc.contributor.author | Parcet, Maria Antonia | |
dc.contributor.author | Avila, Cesar | |
dc.date.accessioned | 2012-09-06T10:16:28Z | |
dc.date.available | 2012-09-06T10:16:28Z | |
dc.date.issued | 2011-02-23 | |
dc.identifier.citation | Brain Research (23 Febr. 2011), vol. 1375, p. 111-1119 | |
dc.identifier.issn | 0006-8993 | |
dc.identifier.uri | http://hdl.handle.net/10234/46128 | |
dc.description.abstract | It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and workingmemory. Thus, our objective was to investigate brain differences between cocaine-dependent subjects and healthy controls during the performance ofaverbalworkingmemorytask. Nineteen comparison men and nineteen cocaine-dependent men performed a 2-back task. Data were acquired on a 1.5-T Siemens Avanto. Image processing and statistical analyses were carried out using SPM5; Biological Parametric Mapping (BPM) was used for further morphometric and correlation analyses. No performance differences were found between groups. However, the dorsal part of the right inferior parietal cortex (BA 40) was less activated in thecocaine-dependentgroup. Cocaine patients did not overactive any brain area when compared with controls. Our results show reduced activation in the brain areas related to the attention system incocaine-dependent men while performing averbalworkingmemorytask. Chronic cocaine use may affect the attentional system in the rightparietal lobe, making patients more prone to attentional deficits. | ca_CA |
dc.description.sponsorShip | This study was supported by grants from FEPAD (Fundación para el Estudio, Prevención y Asistencias a la Drogodependencia), from the“National Plan of Drugs” (Plan Nacional de Drogas), and from the BRAINGLOT, a Spanish Research Network on Bilingualism and Cognitive Neuroscience (Consolider-Ingenio 2010 Programme, Spanish Ministry of Science and Education, CSD2007-00012). Moreover, the study was supported by a Ph.D. fellowship from “Universitat Jaume I” of Castellón (PREDOC/2007/13) | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language | eng | ca_CA |
dc.language.iso | cat | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.rights | © 2010 Elsevier Inc. All rights reserved | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Cocaine | ca_CA |
dc.subject | Functional magnetic resonance imaging | ca_CA |
dc.subject | Parietal cortex | ca_CA |
dc.subject | Attention | ca_CA |
dc.subject | Workingmemory | ca_CA |
dc.subject | Behavioral performance | ca_CA |
dc.title | Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.brainres.2010.12.042 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0006899310027071 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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