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dc.contributor.authorPozo, Óscar J.
dc.contributor.authorVan Eenoo, Peter
dc.contributor.authorDeventer, Koen
dc.contributor.authorDelbeke, Frans T.
dc.date.accessioned2012-05-28T14:36:50Z
dc.date.available2012-05-28T14:36:50Z
dc.date.issued2008
dc.identifierhttp://dx.doi.org/10.1016/j.trac.2008.06.003
dc.identifier.citationTrAC - Trends in Analytical Chemistry, 27, 8, p. 657-671
dc.identifier.issn1659936
dc.identifier.urihttp://hdl.handle.net/10234/39031
dc.description.abstractThe detection of target anabolic steroids in doping analysis has generally been performed by gas chromatography combined with mass spectrometry (GC-MS). However, liquid chromatography combined with tandem mass spectrometry (LC-MS<sup>2</sup>) is gradually becoming more important for this purpose. Also, since non-commercially available anabolic steroids have been found in some doping-control samples, detection and structural determination of unknown steroids has become a challenge for doping-control laboratories. We discuss the potential of different LC-MS and LC-MS<sup>2</sup> scan modes for detection of both target and unknown anabolic steroids. Several modes (e.g., selected reaction monitoring, full scan and product-ion scan) can be successfully used for the detection of target analytes. In order to detect and to characterize unknown steroids and metabolites, the most powerful approach seems to be to combine several scan modes. We use a practical case to illustrate the potential of LC-MS and LC-MS<sup>2</sup> for this purpose. © 2008 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.publisherElsevier
dc.subjectAnabolic steroid
dc.subjectDoping analysis
dc.subjectLiquid chromatography
dc.subjectMass spectrometry
dc.subjectMetabolite
dc.subjectNeutral loss
dc.subjectPrecursor-ion scan
dc.subjectScan mode
dc.subjectTarget
dc.subjectUnknown
dc.titleDetection and characterization of anabolic steroids in doping analysis by LC-MS
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doihttp://dx.doi.org/10.1016/j.trac.2008.06.003
dc.rights.accessRightsinfo:eu-repo/semantics/closedAccess


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