Listar MED_Articles por autoría "6b9bbb74-ca8e-4bec-85e8-8b2d67c91793"

Mostrando ítems 1-4 de 4

    • openAccess   Association between several immune response-related genes and the effectiveness of biological treatments in patients with moderate-to-severe psoriasis 

      Loras Monfort, Alba; Gil-Barrachina, Marta; Hernando, Barbara; Pérez-Pastor, Gemma María; Martinez-Domenech, Alvaro; Mahiques, Laura; PITARCH BORT, GERARD; Valcuende-Cavero, Francisca; Ballester, Rosa; Marques-Torrejon, Maria Angeles; Martinez-Cadenas, Conrado Wiley (2024-01-04)
      Biological therapies are safer and more effective against psoriasis than conventional treatments. Even so, 30–50% of psoriatic patients show an inadequate response, which is associated with individual genetic heterogeneity. ...

    • openAccess   Genetic variants associated with skin photosensitivity in a southern European population from Spain 

      Hernando, Barbara; Sanz-Page, Elena; PITARCH BORT, GERARD; Mahiques, Laura; Valcuende-Cavero, Francisca; Martinez-Cadenas, Conrado Wiley (2018)
      Background/Purpose: Recent GWAS studies, mostly performed in populations of North European origin, have identified the genetic loci associated with pigmentation, sun sensitivity, freckling and skin cancer ...

    • openAccess   Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin 

      Hernando, Barbara; Ibarrola-Villava, Maider; Oltra, Sara S.; Valcuende-Cavero, Francisca; PITARCH BORT, GERARD; Mahiques, Laura; Ribas, Gloria; Martinez-Cadenas, Conrado Wiley (2020)
      Human skin pigmentation results from the enzymatically controlled synthesis of melanin pigments in specialized organelles (melano‐somes) produced within epidermal melanocytes, followed by their transfer to neighboring ...

    • openAccess   The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin 

      Hernando, Barbara; Dietzen, M.; Parra, G.; Gil-Barrachina, Marta; PITARCH BORT, GERARD; Mahiques, Laura; Valcuende-Cavero, Francisca; McGranahan, Nicholas; Martinez-Cadenas, Conrado Elsevier (2021)
      Background: The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also ...