Listar MED_Articles por autoría "3b202d57-a597-4c26-80e1-f17f5b246b76"
Mostrando ítems 1-8 de 8
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Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECTin Guinea Pig: Role of Bitter Taste Agonists
Ortiz, José L.; Ortiz, Amparo; MILARA, JAVIER; Armengot, Miguel; Sanz, Celia; Compañ, Desamparados; Morcillo, Esteban; Cortijo, Julio Public Library of Science (2016)Different image techniques have been used to analyze mucociliary clearance (MCC) in humans, but current small animal MCC analysis using in vivo imaging has not been well defined. Bitter taste receptor (T2R) agonists ... -
JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
MILARA, JAVIER; Ballester, Beatriz; Morell, Anselm; Ortiz, José L.; Escrivá, Juan; Fernández, Estrella; Pérez-Vizcaino, Francisco; Cogolludo, Ángel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio BMJ (2018)Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF ... -
MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease
MILARA, JAVIER; Díaz-Platas, Lucía; Contreras, Sonia; Ribera, Pilar; Roger, Inés; Ballester, Beatriz; Montero, Paula; Cogolludo, Ángel; Morcillo, Esteban; Cortijo, Julio BMC (2018)Background Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD ... -
MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps
MILARA, JAVIER; Morell, Anselm; Ballester, Beatriz; Armengot, Miguel; Morcillo, Esteban; Cortijo, Julio Elsevier (2016)Background Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, interacting with glucocorticoid receptor (GR) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). ... -
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses
MILARA, JAVIER; Ballester, Beatriz; Safont, M. J.; Artigues, Enrique; Escrivá, Juan; Morcillo, Esteban; Cortijo, Julio Springer Nature (2020-09-04)Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that MUC4 was overexpressed in IPF patients ... -
Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
MILARA, JAVIER; Morell, Anselm; de Diego, Alfredo; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio Wiley (2019-01)BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin ... -
Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients
MILARA, JAVIER; Cervera, Angela; de Diego, Alfredo; Sanz, Celia; Juan, Gustavo; Gavaldà, Amadeu; Miralpeix, Montserrat; Morcillo, Esteban; Cortijo, Julio BioMed Central (2016)Background: Inhaled corticosteroid (ICS) with long-acting beta-2 agonists is a well-documented combination therapy for chronic obstructive pulmonary disease (COPD) based on its additive anti-inflammatory properties. By ... -
The JAK2 pathway is activated in idiopathic pulmonary fibrosis
MILARA, JAVIER; Hernandez, Gracia; Ballester, Beatriz; Morell, Anselm; Roger, Inés; Montero, P.; Escrivá, Juan; Lloris, José M.; Molina Molina, Maria; Morcillo, Esteban; Cortijo, Julio BioMed Central (2018)Background: Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...