Listar MED_Articles por autoría "38e98a19-13a1-4819-bfab-02405352d79b"
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Association of TYR SNP rs1042602 with Melanoma Risk and Prognosis
Sevilla Mambrilla, Arrate; Sánchez-Diez, Ana; Cobo Sustacha, Sofía; Izagirre Arribalzaga, Neskuts; Martinez-Cadenas, Conrado; Marti, Rosa M; Puértolas, Teresa; De Unamuno Bustos, Blanca; Bañuls, José; Izu, Rosa; Gardeazabal, Jesús; Asumendi, Aintzane; Boyano, María D.; Alonso, Santos MDPI (2023)Cutaneous melanoma is the most aggressive of skin tumors. In order to discover new biomarkers that could help us improve prognostic prediction in melanoma patients, we have searched for germline DNA variants associated ... -
Comparison of the transcriptional profiles of melanocytes from dark and light skinned individuals under basal conditions and following ultraviolet-b irradiation
López, Saioa; Smith-Zubiaga, I.; García de Galdeano, Alicia; Boyano, Dolores; García, Oscar; Gardeazábal, Jesús; Martinez-Cadenas, Conrado; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Public Library of Science (2015)We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate ... -
Sex and MC1R variants in human pigmentation: Differences in tanning ability and sensitivity to sunlight between sexes
Hernando, Barbara; Ibarrola-Villava, Maider; Peña Chilet, María; Alonso, Santos; Ribas, Gloria; Martinez-Cadenas, Conrado Elsevier (2016) -
Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin
Hernando, Barbara; Ibarrola-Villava, Maider; Fernández, Lara P.; Peña Chilet, María; Llorca-Cardeñosa, Marta J.; Oltra, Sara S.; Alonso, Santos; Boyano, Dolores; Martinez-Cadenas, Conrado; Ribas, Gloria BioMed Central (2016-03)Background Human pigmentation is a polygenic quantitative trait with high heritability. In addition to genetic factors, it has been shown that pigmentation can be modulated by oestrogens and androgens via up- or ... -
The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population
López, Saioa; García, Oscar; Yurrebaso, Iñaki; Flores, Carlos; Acosta-Herrera, Marialbert; Chen, Hua; Gardeazabal, Jesús; Careaga, Jesús María; Boyano, Dolores; Sánchez, Ana; Ratón-Nieto, Juan Antonio; Sevilla, Arrate; Smith-Zubiaga, I.; García de Galdeano, Alicia; Martinez-Cadenas, Conrado; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Public Library of Science (2014)We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population ...