Show simple item record

dc.contributor.authorCollado Sánchez, María Ángeles
dc.contributor.authorRambla Alegre, María
dc.contributor.authorCarda-Broch, Samuel
dc.contributor.authorEsteve-Romero, Josep
dc.date.accessioned2012-03-07T09:23:48Z
dc.date.available2012-03-07T09:23:48Z
dc.date.issued2010
dc.identifier.citationJournal of Liquid Chromatography and Related Technologies (2010), vol. 33, no. 4, p. 513-525
dc.identifier.issn1082-6076
dc.identifier.urihttp://hdl.handle.net/10234/33056
dc.description.abstractA rapid and simple liquid chromatographic procedure using micellar mobile phases is reported for the separation and determination of four quinolones (pipemidic acid, levofloxacin, norfloxacin and moxifloxacin) in pharmaceuticals. This purpose was achieved without any previous pretreatment step in a C18 column using a micellar mobile phase of 0.15 M sodium dodecyl sulphate, 2.5% propanol and 0.5% triethylamine at pH 3, with retention times below 12 min. For detection, the diode-array UV-Vis set at 276 nm was used. The limits of detection and quantification were between 8-51 and 28-171 ng/mL, respectively. This method was validated in terms of intra-day and inter-day precision and accuracy, and robustness. Calibration curves over the concentration range of 0.1-50 μg/mL were linear (r2 > 0.9997) and. Good claim percentages (96–106 %) were obtained in the analysis of pharmaceutical formulations. The results show that the procedure is suitable for the routine analysis of drugs.
dc.format.extent21 p.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.isFormatOfVersió pre-print del document publicat a http://www.tandfonline.com/doi/abs/10.1080/10826070903574519
dc.subjectQuinolone
dc.subjectFluoroquinolone
dc.subjectMicellar mobile phase
dc.subjectSDS
dc.subjectDirect injection
dc.subjectPharmaceutical formulation
dc.subject.lcshLiquid chromatography
dc.subject.lcshQuinolone antibacterial agents
dc.subject.otherCromatografia de líquids
dc.subject.otherQuinolones
dc.titleSimultaneous separation and determination of quinolones in pharmaceuticals by micellar liquid chromatography
dc.typeinfo:eu-repo/semantics/article
dc.rights.holder© Taylor & Francis
dc.identifier.doihttp://dx.doi.org/10.1080/10826070903574519
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record