Simultaneous separation and determination of quinolones in pharmaceuticals by micellar liquid chromatography
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Altres documents de l'autoria: Collado Sánchez, María Ángeles; Rambla Alegre, María; Carda-Broch, Samuel; Esteve-Romero, Josep
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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Títol
Simultaneous separation and determination of quinolones in pharmaceuticals by micellar liquid chromatographyAutoria
Data de publicació
2010Editor
Taylor & FrancisISSN
1082-6076Cita bibliogràfica
Journal of Liquid Chromatography and Related Technologies (2010), vol. 33, no. 4, p. 513-525Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
A rapid and simple liquid chromatographic procedure using micellar mobile phases is reported for the separation and determination of four quinolones (pipemidic acid, levofloxacin, norfloxacin and moxifloxacin) in ... [+]
A rapid and simple liquid chromatographic procedure using micellar mobile phases is reported for the separation and determination of four quinolones (pipemidic acid, levofloxacin, norfloxacin and moxifloxacin) in pharmaceuticals.
This purpose was achieved without any previous pretreatment step in a C18 column using a micellar mobile phase of 0.15 M sodium dodecyl sulphate, 2.5% propanol and 0.5% triethylamine at pH 3, with retention times below 12 min. For detection, the diode-array UV-Vis set at 276 nm was used. The limits of detection and quantification were between 8-51 and 28-171 ng/mL, respectively. This method was validated in terms of intra-day and inter-day precision and accuracy, and robustness. Calibration curves over the concentration range of 0.1-50 μg/mL were linear (r2 > 0.9997) and. Good claim percentages (96–106 %) were obtained in the analysis of pharmaceutical formulations. The results show that the procedure is suitable for the routine analysis of drugs. [-]
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