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dc.contributor.authorMIQUEL, MARTA
dc.contributor.authorNicola, Saleem
dc.contributor.authorGil-Miravet, Isis
dc.contributor.authorGuarque-Chabrera, Julian
dc.contributor.authorSanchez-Hernandez, Aitor
dc.date.accessioned2019-06-05T11:26:30Z
dc.date.available2019-06-05T11:26:30Z
dc.date.issued2019-05
dc.identifier.citationMIQUEL, Marta; NICOLA, Saleem; GIL-MIRAVET, Isis; GUARQUE-CHABRERA, Julian; SÁNCHEZ HERNÁNDEZ, Aitor (2019). A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity. Frontiers in Behavioral Neuroscience, v. 13ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/182688
dc.description.abstractGrowing evidence associates cerebellar abnormalities with several neuropsychiatric disorders in which compulsive symptomatology and impulsivity are part of the disease pattern. Symptomatology of autism, addiction, obsessive-compulsive (OCD), and attention deficit/hyperactivity (ADHD) disorders transcends the sphere of motor dysfunction and essentially entails integrative processes under control of prefrontalthalamic-cerebellar loops. Patients with brain lesions affecting the cortico-striatum thalamic circuitry and the cerebellum indeed exhibit compulsive symptoms. Specifically, lesions of the posterior cerebellar vermis cause affective dysregulation and deficits in executive function. These deficits may be due to impairment of one of the main functions of the cerebellum, implementation of forward internal models of the environment. Actions that are independent of internal models may not be guided by predictive relationships or a mental representation of the goal. In this review article, we explain how this deficit might affect executive functions. Additionally, regionalized cerebellar lesions have been demonstrated to impair other brain functions such as the emergence of habits and behavioral inhibition, which are also altered in compulsive disorders. Similar to the infralimbic cortex, clinical studies and research in animal models suggest that the cerebellum is not required for learning goal-directed behaviors, but it is critical for habit formation. Despite this accumulating data, the role of the cerebellum in compulsive symptomatology and impulsivity is still a matter of discussion. Overall, findings point to a modulatory function of the cerebellum in terminating or initiating actions through regulation of the prefrontal cortices. Specifically, the cerebellum may be crucial for restraining ongoing actions when environmental conditions change by adjusting prefrontal activity in response to the new external and internal stimuli, thereby promoting flexible behavioral control. We elaborate on this explanatory framework and propose a working hypothesis for the involvement of the cerebellum in compulsive and impulsive endophenotypes.ca_CA
dc.format.extent14 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherFrontiers Mediaca_CA
dc.relation.isPartOfFrontiers in Behavioral Neuroscience (2019), v. 13ca_CA
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectCerebellumca_CA
dc.subjectCompulsivityca_CA
dc.subjectAddictionca_CA
dc.subjectImpulsivityca_CA
dc.subjectPredictionca_CA
dc.subjectHabitsca_CA
dc.titleA Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivityca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.3389/fnbeh.2019.00099
dc.relation.projectID1) Universitat Jaume I (PREDOC2014/11); 2)Universitat Jaume I (UJI-14I307.01/1); 3) Ministerio de Economía y Competitividad (MINECO; PSI2015-68600-P); 4) Plan Nacional de Drogas 2017 (PND-132400); and 5) NIH grants (DA044761, DA019473, DA038412).ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://www.frontiersin.org/articles/10.3389/fnbeh.2019.00099/fullca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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