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dc.contributor.authorSalais López, Hugo
dc.contributor.authorAgustín-Pavón, Carmen
dc.contributor.authorLanuza, Enrique
dc.contributor.authorMartinez-Garcia, Fernando
dc.date.accessioned2019-03-07T10:38:13Z
dc.date.available2019-03-07T10:38:13Z
dc.date.issued2018
dc.identifier.citationSalais-Lo´pez H, Agustı´n-Pavo´n C, Lanuza E, Martı´nez-Garcı´a F (2018) The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain. PLoS ONE 13(12): e0208960. https://doi.org/10.1371/ journal.pone.0208960ca_CA
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10234/181745
dc.description.abstractResearch of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of transcription 5 (pSTAT5) after exogenous prolactin administration. Next, we explore possible sexually dimorphic differences by comparing pSTAT5 immunoreactivity in prolactin-supplemented males and females. We also assess the role of testosterone in the regulation of central prolactin signalling in males by comparing intact with castrated prolactin-supplemented males. Prolactin-supplemented males displayed a widespread pattern of pSTAT5 immunoreactivity, restricted to brain centres showing expression of the prolactin receptor. Immunoreactivity for pSTAT5 was present in several nuclei of the preoptic, anterior and tuberal hypothalamus, as well as in the septofimbrial nucleus or posterodorsal medial amygdala of the telencephalon. Conversely, non-supplemented control males were virtually devoid of pSTAT5-immunoreactivity, suggesting that central prolactin actions in males are limited to situations concurrent with substantial hypophyseal prolactin release (e.g. stress or mating). Furthermore, comparison of prolactin-supplemented males and females revealed a significant, female-biased sexual dimorphism, supporting the view that prolactin has a preeminent role in female physiology and behaviour. Finally, in males, castration significantly reduced pSTAT5 immunoreactivity in some structures, including the paraventricular and ventromedial hypothalamic nuclei and the septofimbrial region, thus indicating a region-specific regulatory role of testosterone over central prolactin signalling.ca_CA
dc.format.extent21 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherPublic Library of Scienceca_CA
dc.relation.isPartOfPLoS ONE 13(12) 2018ca_CA
dc.rights© 2018 Salais-Lo´pez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca_CA
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.titleThe maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brainca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0208960
dc.relation.projectIDBFU2016-77691-C2-2-P ; BFU2016-77691-C2-1-P ; PROMETEO/2016/076 ; UJI-B2016-45 ; FPU12/05472ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208960ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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© 2018 Salais-Lo´pez et al. This is an
open access article distributed under the terms of
the Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2018 Salais-Lo´pez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.