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Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus
dc.contributor.author | García-García, Raquel | |
dc.contributor.author | Cruz Gómez, Álvaro Javier | |
dc.contributor.author | Urios, Amparo | |
dc.contributor.author | Mangas-Losada, Alba | |
dc.contributor.author | Forn, Cristina | |
dc.contributor.author | Escudero-García, Desamparados | |
dc.contributor.author | Kosenko, Elena | |
dc.contributor.author | Torregrosa, Isidro | |
dc.contributor.author | Tosca, Joan | |
dc.contributor.author | Giner-Durán, Remedios | |
dc.contributor.author | Serra, Miguel Ángel | |
dc.contributor.author | Avila, Cesar | |
dc.contributor.author | Belloch, Vicente | |
dc.contributor.author | Felipo, Vicente | |
dc.contributor.author | Montoliu, Carmina | |
dc.date.accessioned | 2018-10-30T19:24:17Z | |
dc.date.available | 2018-10-30T19:24:17Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | GARCÍA-GARCÍA, Raquel, et al. Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus. Scientific reports, 2018, 8.1: 9664 | ca_CA |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10234/177130 | |
dc.description.abstract | Patients with minimal hepatic encephalopathy (MHE) show mild cognitive impairment associated with alterations in attentional and executive networks. There are no studies evaluating the relationship between memory in MHE and structural and functional connectivity (FC) changes in the hippocampal system. This study aimed to evaluate verbal learning and long-term memory in cirrhotic patients with (C-MHE) and without MHE (C-NMHE) and healthy controls. We assessed the relationship between alterations in memory and the structural integrity and FC of the hippocampal system. C-MHE patients showed impairments in learning, long-term memory, and recognition, compared to C-NMHE patients and controls. Cirrhotic patients showed reduced fimbria volume compared to controls. Larger volumes in hippocampus subfields were related to better memory performance in C-NMHE patients and controls. C-MHE patients presented lower FC between the L-presubiculum and L-precuneus than C-NMHE patients. Compared to controls, C-MHE patients had reduced FC between L-presubiculum and subiculum seeds and bilateral precuneus, which correlated with cognitive impairment and memory performance. Alterations in the FC of the hippocampal system could contribute to learning and long-term memory impairments in C-MHE patients. This study demonstrates the association between alterations in learning and long-term memory and structural and FC disturbances in hippocampal structures in cirrhotic patients. | ca_CA |
dc.format.extent | 13 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Nature | ca_CA |
dc.relation.isPartOf | Scientific reports, 2018, vol. 8, núm. 1 | ca_CA |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre- ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per- mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ . © The Author(s) 2018 | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.title | Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1038/s41598-018-27978-x | |
dc.relation.projectID | This work was financially supported by Ministerio de Ciencia e Innovación (SAF2014-51851-R) to V.F. and Instituto de Salud Carlos III (FISPI15/00035) to C.M., co-funded-European Regional Development Funds (ERDF); MINECO (PSI2015-67285-R) to C.F., and Consellería Educación Generalitat Valenciana (PROMETEOII/2014/033 to V.F., and ACOMP/2014/026 to C.M.) | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41598-018-27978-x | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-
ative Commons license, and indicate if changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not per-
mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
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© The Author(s) 2018