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dc.contributor.authorFelip-León, Carles
dc.contributor.authorMartínez Arroyo, Olga
dc.contributor.authorDíaz Oltra, Santiago
dc.contributor.authorMiravet, Juan F.
dc.contributor.authorApostolova, Nadezda
dc.contributor.authorGalindo Honrubia, Francisco
dc.date.accessioned2018-10-05T07:33:08Z
dc.date.available2018-10-05T07:33:08Z
dc.date.issued2018-03-01
dc.identifier.citationFELIP-LEÓN, Carles, et al. Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency. Bioorganic & medicinal chemistry letters, 2018, vol. 28, no 5, p. 869-874.ca_CA
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/10234/176591
dc.description.abstractTwo new photoactive compounds (1 and 2) derived from the 9-amidoacridine chromophore have been synthesized and fully characterized. Their abilities to produce singlet oxygen upon irradiation have been compared. The synthesized compounds show very different self-aggregating properties since only 1 present a strong tendency to aggregate in water. Biological assays were conducted with two cell types: hepatoma cells (Hep3B) and human umbilical vein endothelial cells (HUVEC). Photodynamic therapy (PDT) studies carried out with Hep3B cells showed that non-aggregating compound 2 showed photoxicity, ascribed to the production of singlet oxygen, being aggregating compound 1 photochemically inactive. On the other hand suspensions of 1, characterized as nano-sized aggregates, have notable antiproliferative activity towards this cell line in the dark.ca_CA
dc.format.extent6 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfBioorganic & medicinal chemistry letters, 2018, vol. 28, no 5ca_CA
dc.rightsCopyright © Elsevier B.V.ca_CA
dc.subjectself-aggregationca_CA
dc.subjectorganic nanoparticlesca_CA
dc.subject9-Amidoacridineca_CA
dc.subjectphotodynamic therapyca_CA
dc.subjectsinglet oxygenca_CA
dc.titleSynthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiencyca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1016/j.bmcl.2018.02.005
dc.relation.projectIDMinisterio de Economia y Competitividad of Spain: CTQ2015-71004-R; CTQ2012-37735; BES-2013-063296. Universitat Jaume I: P1.1B2015-76ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://www.sciencedirect.com/science/article/pii/S0960894X18300866ca_CA
dc.date.embargoEndDate2020-03-01
dc.contributor.funderTechnical support from SCIC of University Jaume I is acknowledged.ca_CA
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_CA


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