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Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency
dc.contributor.author | Felip-León, Carles | |
dc.contributor.author | Martínez Arroyo, Olga | |
dc.contributor.author | Diaz-Oltra, Santiago | |
dc.contributor.author | Miravet, Juan | |
dc.contributor.author | Apostolova, Nadezda | |
dc.contributor.author | Galindo, Francisco | |
dc.date.accessioned | 2018-10-05T07:33:08Z | |
dc.date.available | 2018-10-05T07:33:08Z | |
dc.date.issued | 2018-03-01 | |
dc.identifier.citation | FELIP-LEÓN, Carles, et al. Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency. Bioorganic & medicinal chemistry letters, 2018, vol. 28, no 5, p. 869-874. | ca_CA |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | http://hdl.handle.net/10234/176591 | |
dc.description.abstract | Two new photoactive compounds (1 and 2) derived from the 9-amidoacridine chromophore have been synthesized and fully characterized. Their abilities to produce singlet oxygen upon irradiation have been compared. The synthesized compounds show very different self-aggregating properties since only 1 present a strong tendency to aggregate in water. Biological assays were conducted with two cell types: hepatoma cells (Hep3B) and human umbilical vein endothelial cells (HUVEC). Photodynamic therapy (PDT) studies carried out with Hep3B cells showed that non-aggregating compound 2 showed photoxicity, ascribed to the production of singlet oxygen, being aggregating compound 1 photochemically inactive. On the other hand suspensions of 1, characterized as nano-sized aggregates, have notable antiproliferative activity towards this cell line in the dark. | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Bioorganic & medicinal chemistry letters, 2018, vol. 28, no 5 | ca_CA |
dc.rights | Copyright © Elsevier B.V. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | self-aggregation | ca_CA |
dc.subject | organic nanoparticles | ca_CA |
dc.subject | 9-Amidoacridine | ca_CA |
dc.subject | photodynamic therapy | ca_CA |
dc.subject | singlet oxygen | ca_CA |
dc.title | Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.bmcl.2018.02.005 | |
dc.relation.projectID | Ministerio de Economia y Competitividad of Spain: CTQ2015-71004-R; CTQ2012-37735; BES-2013-063296. Universitat Jaume I: P1.1B2015-76 | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0960894X18300866 | ca_CA |
dc.date.embargoEndDate | 2020-03-01 | |
dc.contributor.funder | Technical support from SCIC of University Jaume I is acknowledged. | ca_CA |
dc.type.version | info:eu-repo/semantics/acceptedVersion | ca_CA |
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