The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice
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Otros documentos de la autoría: Perez-Rando, Marta; Castillo-Gomez, Esther; Bueno-Fernández, Clara; Nacher, Juan
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Título
The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in miceFecha de publicación
2018-06Editor
Springer VerlagISSN
1863-2653; 1863-2661Cita bibliográfica
PÉREZ-RANDO, Marta, et al. The TrkB agonist 7, 8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice. Brain Structure and Function, 2018, vol. 223, no 5, p. 2393-2408.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://link.springer.com/article/10.1007%2Fs00429-018-1637-xVersión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
BDNF and its receptor TrkB have important roles in neurodevelopment, neural plasticity, learning, and memory. Alterations in TrkB expression have been described in different CNS disorders. Therefore, drugs interacting ... [+]
BDNF and its receptor TrkB have important roles in neurodevelopment, neural plasticity, learning, and memory. Alterations in TrkB expression have been described in different CNS disorders. Therefore, drugs interacting with TrkB, specially agonists, are promising therapeutic tools. Among them, the recently described 7,8-dihydroxyflavone (DHF), an orally bioactive compound, has been successfully tested in animal models of these diseases. Recent studies have shown the influence of this drug on the structure of pyramidal neurons, specifically on dendritic spine density. However, there is no information yet on how DHF may alter the structural dynamics of these neurons (i.e., real-time study of the addition/elimination of dendritic spines and axonal boutons). To gain knowledge on these effects of DHF, we have performed a real-time analysis of spine and axonal dynamics in pyramidal neurons of barrel cortex, using cranial windows and 2-photon microscopy during a chronic oral treatment with this drug. After confirming TrkB expression in these neurons, we found that DHF increased the gain rates of spines and axonal boutons, as well as improved object recognition memory. These results help to understand how the activation of the BDNF-TrkB system can improve basic behavioral tasks through changes in the structural dynamics of pyramidal neurons. Moreover, they highlight DHF as a promising therapeutic vector for certain brain disorders in which this system is altered. [-]
Descripción
This is a pre-print of an article published in Brain Structure and Function. The final authenticated version is available online at: https://doi.org/10.1007/s00429-018-1637-x.
Publicado en
Brain Structure and Function, 2018, vol. 223, no 5Proyecto de investigación
Generalitat Valenciana: PROMETEO2013/069; ACIF/2016/376. Fundacion Alicia Koplowitz. Spanish Ministry of Economy and Competitiveness: SAF2015-68436-R; IJCI-2015-24124; FPU12/03200Derechos de acceso
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