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Chromatografic determination of antibiotics, antiretrovirals and antitumor drugs in biological samples and/or food
dc.contributor.author | Castro Alcázar, Soraya | |
dc.contributor.other | Esteve Cano, Vicente José | |
dc.contributor.other | Universitat Jaume I. Departament de Química Inorgànica i Orgànica | |
dc.date.accessioned | 2018-10-01T11:59:53Z | |
dc.date.available | 2018-10-01T11:59:53Z | |
dc.date.issued | 2018-07 | |
dc.identifier.uri | http://hdl.handle.net/10234/176425 | |
dc.description | Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018 | ca_CA |
dc.description.abstract | This thesis reviews the analytical determination by liquid chromatography of different antibiotic groups in biological samples. The analysis of antibiotics is important due to regulatory and public attention to exposure risk of antibiotics, as well as veterinary applications or residual waters. Results showed that their determination is mostly obtained by HPLC, using C18 columns, excluding glycopeptides due to their lack of chromophore groups. Common mobile phases are water, acetonitrile and methanol, among others like ammonium acetate or ammonium formate. Average retention times of these analyses are run 20-30min with column temperatures from 15-45ºC and injection volumes of 10-20µL. Detection is resulted by UV using wavelengths from 300 to 400nm generally, as well as MS/MS detection in positive mode, excluding glycopeptides where fluorescence detection was noticed. Finally, results have shown CV(%) and RSD(%) below 20%, recoveries under acceptable limits, 65-100%. LODs and LOQs exhibited ranges of ng/L, resulting into an adequate analysis of antibiotic. In conclusion, management and control of antibiotics has to be established in the future, in order to set and obtain on-line detection protocols for unknown metabolites and the transformation products of antibiotics in population or veterinary samples, as well as environmental samples. | ca_CA |
dc.format.extent | 46 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universitat Jaume I | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Grau en Química | ca_CA |
dc.subject | Grado en Química | ca_CA |
dc.subject | Bachelor's Degree in Chemistry | ca_CA |
dc.title | Chromatografic determination of antibiotics, antiretrovirals and antitumor drugs in biological samples and/or food | ca_CA |
dc.type | info:eu-repo/semantics/bachelorThesis | ca_CA |
dc.educationLevel | Estudios de Grado | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
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Grau en Química [265]
QU0943