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dc.contributor.authorLlueca, Antoni
dc.contributor.authorEscrig-Sos, Javier
dc.date.accessioned2018-06-13T07:35:53Z
dc.date.available2018-06-13T07:35:53Z
dc.date.issued2018-01
dc.identifier.citationLLUECA, Antoni; ESCRIG SOS, Javier. (2018). Prognostic value of peritoneal cancer index in primary advanced ovarian cancer. European Journal of Surgical Oncology, v. 44, Issue 1, p. 163-169ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/175129
dc.description.abstractBackground Effective tumor debulking is a major factor associated with a favorable prognosis in patients with advanced ovarian cancer (AOC). However, FIGO staging fails to take full account of the extent of the disease in the peritoneum, making it difficult to plan appropriate surgical treatment. In contrast, the peritoneal cancer index (PCI) can provide more detailed information about peritoneal spread. Method We evaluated the prognostic value of PCI and its association with clinicopathological features in patients with AOC. Data for 80 patients with AOC who underwent primary debulking surgery were analyzed retrospectively. PCI scores of 0–39 were calculated based on the sizes of lesions in 13 abdominopelvic regions, and patients were classified into three categories with scores of 1–10, 11–20, and >20, respectively. Clinicopathological features, including the presence of residual tumor after surgery and the incidence of postoperative complications, were assessed in relation to PCI score. Results PCI was significantly associated with suboptimal surgery and postoperative complications, as well as with preoperative CA125, ascites, prolonged surgery, FIGO stage, positive aortic lymph nodes, prolonged hospitalization, and number of visceral resections. Overall and disease-free survival was also associated with PCI, with an optimal cut-off value of 15. Multivariate analysis identified age, residual tumor, and PCI as independent prognostic factors for survival. A PCI >10 is positively associated with a poor prognosis in patients with AOC. Conclusion Given the importance of effective tumor debulking, PCI may provide important information for surgical planning in patients with AOC.ca_CA
dc.format.extent7 p.ca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfEuropean Journal of Surgical Oncology (2018), v. 44, Issue 1ca_CA
dc.subjectAdvanced ovarian cancerca_CA
dc.subjectDebulking surgeryca_CA
dc.subjectPeritoneal cancer indexca_CA
dc.subjectPrognosisca_CA
dc.subjectResidual tumorca_CA
dc.subjectSurvivalca_CA
dc.titlePrognostic value of peritoneal cancer index in primary advanced ovarian cancerca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1016/j.ejso.2017.11.003
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttps://www.sciencedirect.com/science/article/pii/S0748798317309642?via%3Dihubca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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