Prognostic value of peritoneal cancer index in primary advanced ovarian cancer
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https://doi.org/10.1016/j.ejso.2017.11.003 |
Metadatos
Título
Prognostic value of peritoneal cancer index in primary advanced ovarian cancerFecha de publicación
2018-01Editor
ElsevierCita bibliográfica
LLUECA, Antoni; ESCRIG SOS, Javier. (2018). Prognostic value of peritoneal cancer index in primary advanced ovarian cancer. European Journal of Surgical Oncology, v. 44, Issue 1, p. 163-169Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0748798317309642?via%3DihubVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background
Effective tumor debulking is a major factor associated with a favorable prognosis in patients with advanced ovarian cancer (AOC). However, FIGO staging fails to take full account of the extent of the ... [+]
Background
Effective tumor debulking is a major factor associated with a favorable prognosis in patients with advanced ovarian cancer (AOC). However, FIGO staging fails to take full account of the extent of the disease in the peritoneum, making it difficult to plan appropriate surgical treatment. In contrast, the peritoneal cancer index (PCI) can provide more detailed information about peritoneal spread.
Method
We evaluated the prognostic value of PCI and its association with clinicopathological features in patients with AOC. Data for 80 patients with AOC who underwent primary debulking surgery were analyzed retrospectively. PCI scores of 0–39 were calculated based on the sizes of lesions in 13 abdominopelvic regions, and patients were classified into three categories with scores of 1–10, 11–20, and >20, respectively. Clinicopathological features, including the presence of residual tumor after surgery and the incidence of postoperative complications, were assessed in relation to PCI score.
Results
PCI was significantly associated with suboptimal surgery and postoperative complications, as well as with preoperative CA125, ascites, prolonged surgery, FIGO stage, positive aortic lymph nodes, prolonged hospitalization, and number of visceral resections. Overall and disease-free survival was also associated with PCI, with an optimal cut-off value of 15. Multivariate analysis identified age, residual tumor, and PCI as independent prognostic factors for survival. A PCI >10 is positively associated with a poor prognosis in patients with AOC.
Conclusion
Given the importance of effective tumor debulking, PCI may provide important information for surgical planning in patients with AOC. [-]
Publicado en
European Journal of Surgical Oncology (2018), v. 44, Issue 1Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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