Design and Synthesis of Cysteine Protease Inhibitors
Metadatos
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INVESTIGACIONMetadatos
Título
Design and Synthesis of Cysteine Protease InhibitorsAutoría
Fecha de publicación
2017-09-08Editor
MDPIISSN
2504-3900Cita bibliográfica
Gonzalez, Florenci V. 2017. "Design and Synthesis of Cysteine Protease Inhibitors." Proceedings 1, no. 6: 672.Tipo de documento
info:eu-repo/semantics/conferenceObjectVersión de la editorial
http://www.mdpi.com/2504-3900/1/6/672Versión
info:eu-repo/semantics/publishedVersionResumen
We have been preparing new dipeptidyl inhibitors against parasitic cysteine proteases cruzain (related to Chagas disease) and rhodesain (related to Sleeping Sickness disease), and against human cathepsins. Inhibitors ... [+]
We have been preparing new dipeptidyl inhibitors against parasitic cysteine proteases cruzain (related to Chagas disease) and rhodesain (related to Sleeping Sickness disease), and against human cathepsins. Inhibitors display new warheads embedded into a dipeptidic framework. Dipeptidyl epoxyesters1 and Dipeptidyl enoates2 are highly potent irreversible inhibitors of cruzain and rhodesain. We also prepared an oxidized version of well-known Vinylsulfones (Epoxysulfones3) as inhibitors of human cathepsins. Recently, we have reported the synthesis of Dipeptidyl nitroalkenes4 as a new type of highly potent covalent reversible inhibitors of cysteine proteases exhibiting certain selectivity for the parasitic cysteine proteases rhodesain and cruzain. [-]
Descripción
Resum de la ponència presentada al 1st Molecules Medicinal Chemistry Symposium. Barcelona, 8 september 2017
Publicado en
1st Molecules Medicinal Chemistry Symposium. Barcelona, 8 september 2017Datos relacionados
https://sciforum.net/conference/MMCS2017/MMCS%202017-Second%20Session:%20To%20be%20determinedProyecto de investigación
Generalitat Valenciana (AICO/2016/32)Derechos de acceso
info:eu-repo/semantics/openAccess
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