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dc.contributor.authorDomínguez Mafé, Eloy
dc.contributor.authorPalau, Patricia
dc.contributor.authorNúñez, Eduardo
dc.contributor.authorRamón, José María
dc.contributor.authorLópez, Laura
dc.contributor.authorMelero, Joana
dc.contributor.authorBellver, Alejandro
dc.contributor.authorSantas, Enrique
dc.contributor.authorChorro, Francisco J.
dc.contributor.authorNúñez, Julio
dc.date.accessioned2018-05-15T09:43:19Z
dc.date.available2018-05-15T09:43:19Z
dc.date.issued2018
dc.identifier.citationDOMINGUEZ MAFÉ, Eloy; PALAU SAMPIO, Patricia; NÚÑEZ, Eduardo; RAMÓN, José María; LÓPEZ, Laura; MELERO, Joana; BELLVER, Alejandro; SANTAS, Enrique; CHORRO, Francisco J.; NÚÑEZ, Julio. (2018). Heart rate response and functional capacity in patients with chronic heart failure with preserved ejection fraction. ESC Heart Failure (2018), onlineca_CA
dc.identifier.urihttp://hdl.handle.net/10234/174681
dc.description.abstractAims: The mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) are not yet elucidated. Chronotropic incompetence has emerged as a potential mechanism. We aimed to evaluate whether heart rate (HR) response to exercise is associated to functional capacity in patients with symptomatic HFpEF. Methods and results We prospectively studied 74 HFpEF patients [35.1% New York Heart Association Class III, 53% fe- male, age (mean ± standard deviation) 72.5 ± 9.1 years, and 59.5% atrial fi brillation]. Functional performance was assessed by peak oxygen consumption (peak VO 2 ). The mean (standard deviation) peak VO 2 was 10 ± 2.8 mL/min/kg. The following chronotropic parameters were calculated: Delta-HR (HR at peak exercise - HR at rest), chronotropic index (CI) = (HR at peak exercise - resting HR)/[(220 - age) - resting HR], and CI according to the equation developed by Keteyian et al . (CIK) (HR at peak exercise - HR at rest)/[119 + (HR at rest/2) (age/2) - 5 - HR at rest]. In a bivariate setting, peak VO 2 was positively and signi fi cantly correlated with Delta-HR ( r = 0.35, P = 0.003), CI ( r = 0.27, P = 0.022), CIK ( r = 0.28, P = 0.018), and borderline with HR at peak exercise ( r = 0.22, P = 0.055). In a multivariable linear regression analysis that included clinical, analytical, echocardiographic, and functional capacity covariates, the chronotropic parameters were positively associated with peak VO 2 . We found a linear relationship between Delta-HR and peak VO 2 ( β coef fi cient of 0.03; 95% con fi dence interval: 0.004 – 0.05; P = 0.030); conversely, the association among CIs and peak VO 2 was exponen- tially shaped. Conclusions In patients with chronic HFpEF, the HR response to exercise was positively associated to patient ’ s functional capacity.ca_CA
dc.format.extent7 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherWileyca_CA
dc.relation.isPartOfESC Heart Failure (2018), onlineca_CA
dc.rightsAttribution-NonCommercial*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectHeart failure with preserved ejection fractionca_CA
dc.subjectFunctional capacityca_CA
dc.subjectChronotropic responseca_CA
dc.titleHeart rate response and functional capacity in patients with chronic heart failure with preserved ejection fractionca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/ehf2.12281
dc.relation.projectIDThis work was supported in part by grants from Sociedad Española de Cardiología: Investigación Clínica en Cardiología, Grant SEC 2015, CIBER CV 16/11/00420, 16/11/00403, FEDER, and PIE15/00013.ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/ehf2.12281ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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