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Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn’s disease with fecal calprotectin
dc.contributor.author | Vázquez Morón, Juan María | |
dc.contributor.author | Pallarés Manrique, Héctor | |
dc.contributor.author | Machancoses, Francisco H. | |
dc.contributor.author | Ramos Lora, Manuel | |
dc.contributor.author | Ruiz Frutos, Carlos | |
dc.date.accessioned | 2018-04-27T18:05:53Z | |
dc.date.available | 2018-04-27T18:05:53Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | VÁZQUEZ-MORÓN, Juan María, et al. Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn's disease with fecal calprotectin. Revista Española de Enfermedades Digestivas, 2017, vol. 109, núm. 2, p.130-136 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/174396 | |
dc.description.abstract | Background: Fecal biomarkers, especially fecal calprotectin, are useful for predicting endoscopic activity in Crohn’s disease; however, the cut-off point remains unclear. The aim of this paper was to analyze whether faecal calprotectin and M2 pyruvate kinase are good tools for generating highly accurate scores for the prediction of the state of endoscopic activity and mucosal healing. Methods: The simple endoscopic score for Crohn’s disease and the Crohn’s disease activity index was calculated for 71 patients diagnosed with Crohn’s. Fecal calprotectin and M2-PK were measured by the enzyme-linked immunosorbent assay test. Results: A fecal calprotectin cut-off concentration of ≥ 170 μg/g (sensitivity 77.6%, specificity 95.5% and likelihood ratio +17.06) predicts a high probability of endoscopic activity, and a fecal calprotectin cut-off of ≤ 71 μg/g (sensitivity 95.9%, specificity 52.3% and likelihood ratio -0.08) predicts a high probability of mucosal healing. Three clinical groups were identified according to the data obtained: endoscopic activity (calprotectin ≥ 170), mucosal healing (calprotectin ≤ 71) and uncertainty (71 > calprotectin < 170), with significant differences in endoscopic values (F = 26.407, p < 0.01). Clinical activity or remission modified the probabilities of presenting endoscopic activity (100% vs 89%) or mucosal healing (75% vs 87%) in the diagnostic scores generated. M2-PK was insufficiently accurate to determine scores. Conclusions: The highly accurate scores for fecal calprotectin provide a useful tool for interpreting the probabilities of presenting endoscopic activity or mucosal healing, and are valuable in the specific clinical context. | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | ARAN ediciones | ca_CA |
dc.relation.isPartOf | Revista Española de Enfermedades Digestivas, 2017, vol. 109, núm. 2, p.130-136 | ca_CA |
dc.rights | La Revista Española de Enfermedades Digestivas (REED) es una revista open access, lo que quiere decir que todo su contenido es accesible libremente sin cargo para el usuario individual y sin fines comerciales. Los usuarios individuales están autorizados a leer, descargar, copiar, distribuir, imprimir, buscar o enlazar a los textos completos de los artículos de esta revista sin permiso previo del editor o del autor, de acuerdo con la definición BOAI (Budapest Open Access Initiative) de open access. La reutilización de los trabajos puede hacerse siempre y cuando el trabajo no se altere en su integridad y sus autores sean adecuadamente referenciados o citados en sucesivos usos, y sin derecho a la producción de obras derivadas. © Copyright 2018. Sociedad Española de Patología Digestiva (SEPD) y © Arán Ediciones, S.L. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | fecal calprotectin | ca_CA |
dc.subject | predicting cut-offs | ca_CA |
dc.subject | endoscopic activity | ca_CA |
dc.subject | mucosal healing | ca_CA |
dc.title | Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn’s disease with fecal calprotectin | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.17235/reed.2017.4542/2016 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.reed.es/ArticuloFicha.aspx?id=1432&hst=0&idR=45&tp=1&AspxAutoDetectCookieSupport=1 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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