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dc.contributor.authorOrozco Beltrán, Domingo
dc.contributor.authorGil Guillén, Vicente F.
dc.contributor.authorRedón, Josep
dc.contributor.authorMartín Moreno, José M.
dc.contributor.authorPallarés-Carratalá, Vicente
dc.contributor.authorNavarro Pérez, Jorge
dc.contributor.authorValls Roca, Francisco
dc.contributor.authorSanchis-Domenech, Carlos
dc.contributor.authorFernández Giménez, Antonio
dc.contributor.authorPérez Navarro, Ana M.
dc.contributor.authorBertomeu-Martínez, Vicente
dc.contributor.authorCordero, Alberto
dc.contributor.authorPascual de la Torre, Manuel
dc.contributor.authorTrillo, José L.
dc.contributor.authorCarratala-Munuera, Concepcion
dc.contributor.authorPita Fernández, Salvador
dc.contributor.authorUsó, Ruth
dc.contributor.authorDurazo-Arvizu, Ramon
dc.contributor.authorCooper, Richard
dc.contributor.authorSanz, Ginés
dc.contributor.authorCastellano, José M.
dc.contributor.authorAscaso, Juan F
dc.contributor.authorCarmena, Rafael
dc.contributor.authorTellez-Plaza, Maria
dc.contributor.authorESCARVAL Study Group
dc.contributor.authorBertomeu-González, Vicente
dc.date.accessioned2018-01-08T10:57:23Z
dc.date.available2018-01-08T10:57:23Z
dc.date.issued2017
dc.identifier.citationOrozco-Beltran D, Gil-Guillen VF, Redon J, Martin-Moreno JM, Pallares-Carratala V, NavarroPerez J, et al. (2017) Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study. PLoS ONE 12(10): e0186196. https://doi.org/10.1371/journal. pone.0186196ca_CA
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10234/171601
dc.description.abstractIntroduction The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. Methods This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008–2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles. Results 51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/HDL-Cholesterol: 8.94, 15.09, 6.92. Conclusions In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers.ca_CA
dc.format.extent20 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherPublic Library of Scienceca_CA
dc.relation.isPartOfPLoS ONE 12(10): e0186196ca_CA
dc.rights© 2017 Orozco-Beltran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca_CA
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleLipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK studyca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1371/journal. pone.0186196
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186196ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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© 2017 Orozco-Beltran et al. This is an
open access article distributed under the terms of
the Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Except where otherwise noted, this item's license is described as © 2017 Orozco-Beltran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.