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dc.contributor.authorCebrián-Silla, Arantxa
dc.contributor.authorAlfaro-Cervelló, Clara
dc.contributor.authorHerranz-Pérez, Vicente
dc.contributor.authorKaneko, Naoko
dc.contributor.authorPark, Dae Hwi
dc.contributor.authorSawamoto, Kazunobu
dc.contributor.authorAlvarez-Buylla, Arturo
dc.contributor.authorLim, Daniel A.
dc.contributor.authorGarcía-Verdugo, Jose Manuel
dc.date.accessioned2017-12-20T17:07:28Z
dc.date.available2017-12-20T17:07:28Z
dc.date.issued2017
dc.identifier.citationCebrián-Silla, A., Alfaro-Cervelló, C., Herranz-Pérez, V., Kaneko, N., Park, D. H., Sawamoto, K., ... & García-Verdugo, J. M. (2017). Unique organization of the nuclear envelope in the post-natal quiescent neural stem cells. Stem Cell Reports, 9(1), 203-216.ca_CA
dc.identifier.issn2213-6711
dc.identifier.urihttp://hdl.handle.net/10234/171294
dc.description.abstractNeural stem cells (B1 astrocytes; NSCs) in the adult ventricular-subventricular-zone (V-SVZ) originate in the embryo. Surprisingly, recent work has shown that B1 cells remain largely quiescent. They are reactivated postnatally to function as primary progenitors for neurons destined for the olfactory bulb and some corpus callosum oligodendrocytes. The cellular and molecular properties of quiescent B1 cells remain unknown. Here we found that a subpopulation of B1 cells has a unique nuclear envelope invagination specialization similar to envelope-limited chromatin sheets (ELCS), reported in certain lymphocytes and some cancer cells. Using molecular markers, [3H]thymidine birth-dating, and Ara-C, we found that B1 cells with ELCS correspond to quiescent NSCs. ELCS begin forming in embryonic radial glia cells and represent a specific nuclear compartment containing particular epigenetic modifications and telomeres. These results reveal a unique nuclear compartment in quiescent NSCs, which is useful for identifying these primary progenitors and study their gene regulation.ca_CA
dc.format.extent14 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevier (Cell Press)ca_CA
dc.relation.isPartOfStem Cell Reports, 2017, vol. 9, núm. 1, p. 203-216ca_CA
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2017 The Author(s)ca_CA
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleUnique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cellsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.stemcr.2017.05.024
dc.relation.projectIDThis research was supported by the Prometeo grant PROMETEOII/2014/075 and the MINECO/FEDER grant ( BFU2015-64207-P ). A.C.-S. was supported by the MINECO scholarship (FPU, AP-2010-4264 ). JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (Nagoya City University).ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30231-Xca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
© 2017 The Author(s)
Excepto si se señala otra cosa, la licencia del ítem se describe como: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2017 The Author(s)