Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Sanchez Peris, Maria; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressionsFecha de publicación
2017-04Editor
WileyISSN
1747-0277; 1747-0285Cita bibliográfica
SÁNCHEZ‐PERIS, María, et al. Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase‐related gene expressions. Chemical biology & drug design, 2017, vol. 89, no 4, p. 577-584.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12880/fullVersión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds ... [+]
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their ability to downregulate the secretion of the VEGF protein and the expression of the VEGF, hTERT, and c-Myc genes; the two latter involved in the activation of telomerase in tumoral cells. Some of the synthetized derivatives showed promising pharmacological features as they exhibited IC50 values in low micromolar range, good therapeutic margins, and a multiple mode of action on tumor cells based on the inhibition of VEGF and, at the same time, of the expression of genes related to the activation of telomerase. [-]
Publicado en
Chemical biology & drug design, 2017, vol. 89, no 4, p. 577-584Proyecto de investigación
Ministerio de Economia y Competitividad of Spain / CTQ201452949-P; Conselleria d' Empresa, Universitat i Ciencia de la Generalitat Valenciana / PROMETEO/2013/027 and ACOMP/2014/274; University Jaume I / PI-1B2011-37Derechos de acceso
Copyright © John Wiley & Sons, Inc.
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- QUIO_Articles [690]