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Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene
dc.contributor.author | Llop, Sabrina | |
dc.contributor.author | Murcia, Mario | |
dc.contributor.author | Álvarez Pedrerol, Mar | |
dc.contributor.author | Grimalt, Joan O. | |
dc.contributor.author | SANTA MARINA, LORETO | |
dc.contributor.author | Julvez, Jordi | |
dc.contributor.author | Goñi-Irigoyen, Fernando | |
dc.contributor.author | Espada, Mercedes | |
dc.contributor.author | Ballester, Ferran | |
dc.contributor.author | Rebagliato, Marisa | |
dc.contributor.author | López Espinosa, María José | |
dc.date.accessioned | 2017-10-02T09:35:27Z | |
dc.date.available | 2017-10-02T09:35:27Z | |
dc.date.issued | 2017-04-08 | |
dc.identifier.citation | LLOP, Sabrina; MURCIA, Mario; ÁLVAREZ-PEDREROL, Mar; GRIMALT, Joan O.; SANTA-MARINA RODRÍGUEZ, Loreto; JÚLVEZ, Jordi; GOÑI-IRIGOYEN, Fernando; ESPADA, Mercedes; BALLESTER, Ferran; REBAGLIATO, Marisa; LÓPEZ ESPINOSA, María José. Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene. Environment International (2017), v. 104, p. 83-90 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/169106 | |
dc.description.abstract | Introduction: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action. Aim: To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes. Methods: The study population (n = 1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003–2006). Hexachlorobenzene (HCB), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4´-DDE), b-hexachlorocyclohexane (b-HCH), polychlorobiphenyl (PCB) congeners 138, 153 and 180, thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) were measured in serum samples taken during the first trimester of pregnancy (mean [standard deviation (SD)]: 13.5 [2] weeks of gestation). Polymorphisms in DIO1 (rs2235544) and DIO2 (rs12885300) were genotyped in maternal DNA. Sociodemographic and dietary characteristics were obtained by questionnaire. Results: A 2-fold increase in HCB was associated with lower TT3 (% change = − 1.48; 95%CI: − 2.36, − 0.60). Women in the third tertile for b-HCH had lower TT3 (% change = − 3.19; 95%CI: − 5.64, − 0.67). The interactions between DIO1 rs2235544 and PCB153 and b-HCH were statistically significant. The inverse association between PCB153 and TT3 was the strongest among women with AA genotype. Women with CC genotype presented the strongest inverse association between b-HCH and FT4. Conclusion: Exposure to HCB and b-HCH was associated to a disruption in maternal TT3. The DIO1 rs2235544 SNP modified the association between exposure to some of the OCs (specifically b-HCH and PCB153) and maternal thyroid hormone levels. These results strengthen the hypothesis that DIO enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs. Abbreviations 4,4′-DDE1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene b-HCHb-hexachlorocyclohexane DIOdeiodinase FT4free thyroxine HCBHexachlorobenzene LODlimit of detection OCsorganochlorine compounds PCBspolychlorobiphenyls TBGthyroxine-binding globulin THthyroid hormones TSHthyroid stimulating hormone TTRtransthyretin TT3total triiodothyronine | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Environment International (2017), v. 104 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Pregnancy | ca_CA |
dc.subject | Thyroid | ca_CA |
dc.subject | Organochlorine compounds | ca_CA |
dc.subject | Deiodinase enzymes | ca_CA |
dc.subject | Fetal development | ca_CA |
dc.title | Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.envint.2016.12.013 | |
dc.relation.projectID | This work was supported by grants from the Instituto de Salud Carlos III [Red INMA G03/176 and CB06/02/0041]; the Spanish Ministry of Health [FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 04/1436, 04/2018, 05/1079, 05/1052, 06/1213, 07/0314, 08/1151, 09/02647, 09/2311, 11/01007, 11/02591, 11/02038, 13/1944, 13/2032, 13/2429, 14/00891, 14/01687, and 16/1288] and Miguel Servet-FEDER [CP11/0178, MS14/00108, and MS15/0025]; the Conselleria de Sanitat; Generalitat Valenciana; Generalitat de Catalunya-CIRIT [1999SGR 00241]; Department of Health of the Basque Government [2005111093 and 2009111069]; Department of Education of the Basque Government (BFI-2010_160) pre-doctoral fellowship; the Provincial Government of Gipuzkoa [DFG06/004 and DFG08/001]; FISABIO [UGP-15-230]. | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0160412016303646?via%3Dihub | ca_CA |
dc.date.embargoEndDate | 2019-04-07 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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