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Evidence of an epistatic effect between Dysbindin-1 and Neuritin-1 genes on the risk for schizophrenia spectrum disorders
dc.contributor.author | Prats, Claudia | |
dc.contributor.author | Arias, Barbara | |
dc.contributor.author | Moya-Higueras, Jorge | |
dc.contributor.author | Pomarol Clotet, Edith | |
dc.contributor.author | Parellada, Mara | |
dc.contributor.author | González Pinto, Ana | |
dc.contributor.author | Peralta, Víctor | |
dc.contributor.author | Ibáñez, Manuel I | |
dc.contributor.author | Martín, M. | |
dc.contributor.author | Fañanás Saura, Lourdes | |
dc.contributor.author | Fatjó-Vilas, Mar | |
dc.date.accessioned | 2017-08-30T08:34:06Z | |
dc.date.available | 2017-08-30T08:34:06Z | |
dc.date.issued | 2017-02 | |
dc.identifier.citation | PRATS, Claudia; ARIAS SAMPÉRIZ, Bárbara; MOYA HIGUERAS, Jorge; POMAROL CLOTET, Edith; PARELLADA, Mara; GONZÁLEZ PINTO, Ana; PERALTA, Víctor; IBÁÑEZ RIBES, Manuel Ignacio; MARTÍN, M.; FAÑANÁS SAURA, Lourdes; FATJÓ-VILAS, Mar. Evidence of an epistatic effect between Dysbindin-1 and Neuritin-1 genes on the risk for schizophrenia spectrum disorders. European Psychiatry (2017), v. 40, p. 60-64 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/168521 | |
dc.description.abstract | Background The interest in studying gene–gene interactions is increasing for psychiatric diseases such as schizophrenia-spectrum disorders (SSD), where multiple genes are involved. Dysbindin-1 (DTNBP1) and Neuritin-1 (NRN1) genes have been previously associated with SSD and both are involved in synaptic plasticity. We aimed to study whether these genes show an epistatic effect on the risk for SSD. Methods The sample comprised 388 SSD patients and 397 healthy subjects. Interaction was tested between: (i) three DTNBP1 SNPs (rs2619537, rs2743864, rs1047631) related to changes in gene expression; and (ii) an haplotype in NRN1 previously associated with the risk for SSD (rs645649-rs582262: HAP-risk C-C). Results An interaction between DTNBP1 rs2743864 and NRN1 HAP-risk was detected by using the model based multifactor dimensionality reduction (MB-MDR) approach (P = 0.0049, after permutation procedure), meaning that the risk for SSD is significantly higher in those subjects carrying both the A allele of rs2743864 and the HAP-risk C-C. This interaction was confirmed by using a logistic regression model (P = 0.033, OR (95%CI) = 2.699 (1.08–6.71), R2 = 0.162). Discussion Our results suggest that DTNBP1 and NRN1 genes show a joint effect on the risk for SSD. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate signalling suggests that our findings could be of value as a link to the schizophrenia aetiology. | ca_CA |
dc.format.extent | 5 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Schizophrenia-spectrum disorders (SSD) | ca_CA |
dc.subject | Epistatic effect | ca_CA |
dc.subject | DTNBP1 | ca_CA |
dc.subject | NRN1 | ca_CA |
dc.title | Evidence of an epistatic effect between Dysbindin-1 and Neuritin-1 genes on the risk for schizophrenia spectrum disorders | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.eurpsy.2016.07.006 | |
dc.relation.projectID | This study was supported by: (i) Intramural Project CIBERSAM (P91E), (ii) ERA-NET-NEURON-PIM2010ERN, (iii) the Spanish Ministry of Economy and Competitivity, Instituto de Salud Carlos III (PI15/01420 and PI12/00018) – Ayuda cofinanciada por el Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa”. Thanks to: (i) the Comissionat per a Universitats i Recerca del DIUE (2014SGR1636), (ii) Universitat de Barcelona and APIF-IBUB grant 2014. | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0924933816300918 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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