Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage
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Otros documentos de la autoría: Almansa, Inmaculada; Barcia, Jorge M; López-Pedrajas, Rosa; Muriach, Maria; Miranda, María; Romero, Francisco J.
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Título
Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative DamageAutoría
Fecha de publicación
2013Editor
Hindawi Publishing CorporationISSN
1942-0900; 1942-0994Cita bibliográfica
Inmaculada Almansa, Jorge M. Barcia, Rosa López-Pedrajas, María Muriach, María Miranda, and Francisco Javier Romero, “Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 296898, 5 pages, 2013. doi:10.1155/2013/296898Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.hindawi.com/journals/omcl/2013/296898/Versión
info:eu-repo/semantics/publishedVersionResumen
Naltrexone, an antagonist of 𝜇�-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of
the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert ... [+]
Naltrexone, an antagonist of 𝜇�-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of
the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical
alterations, in the hippocampus and serum of chronic alcoholic adult rats. Malondialdehyde concentration was increased and
glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats. Naltrexone treatment restored
these alterations. The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used. Thus this apparent
protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed. [-]
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Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 296898Derechos de acceso
info:eu-repo/semantics/openAccess
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