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dc.contributor.authorMoreno Rius, Josep
dc.contributor.authorMiquel, Marta
dc.date.accessioned2017-05-05T07:22:42Z
dc.date.available2017-05-05T07:22:42Z
dc.date.issued2017-04-01
dc.identifier.citationMORENO RIUS, Josep; MIQUEL SALGADO-ARAUJO, Marta. The cerebellum in drug craving. Drug and Alcohol Dependence (2017), v. 173, pp. 151–158ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/167482
dc.description.abstractCraving has been considered one of the core features of addiction. It can be defined as the urge or conscious desire to use a drug elicited by the drug itself, drug-associated cues or stressors. Craving plays a major role in relapse, even after prolonged periods of abstinence, as well as in the maintenance of drug seeking in non-abstinent addicts. The circuitry of craving includes medial parts of the prefrontal cortex, ventral striatal zones, ventral tegmental area, ventral pallidum, and limbic regions. Interestingly, the cerebellum shows reciprocal loops with many of these areas. The cerebellum has been linked traditionally to motor functions but increasing evidence indicates that this part of the brain is also involved in functions related to cognition, prediction, learning, and memory. Moreover, the functional neuroimaging studies that have addressed the study of craving in humans repeatedly demonstrate cerebellar activation when craving is elicited by the presentation of drug-related cues. However, the role of cerebellar activity in these craving episodes remains unknown. Therefore, the main goal of this review is to provide a brief update on craving studies and the traditional neural basis of this phenomenon, and then discuss and propose a hypothesis for the function of the cerebellum in craving episodes.ca_CA
dc.description.sponsorShipThis work was supported by grant UJI (14I307.01/1)ca_CA
dc.format.extent33 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isospaca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfDrug and Alcohol Dependence (2017), v. 173ca_CA
dc.subjectCravingca_CA
dc.subjectCerebellumca_CA
dc.subjectMemoryca_CA
dc.subjectCue reactivityca_CA
dc.subjectPredictionca_CA
dc.subjectExpectationsca_CA
dc.titleThe cerebellum in drug cravingca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1016/j.drugalcdep.2016.12.028
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S037687161730073Xca_CA


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