Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat
Scholar | Otros documentos del autor: Linley, Stephanie B.; Olucha Bordonau, Francisco E.; Vertes, Robert P.
MetadatosMostrar el registro completo del ítem
TítuloPattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat
Fecha de publicación2016-06
As is well recognized, serotonergic (5-HT) fibers distribute widely throughout the forebrain, including the amygdala. Although a few reports have examined the 5-HT innervation of select nuclei of the amygdala in the ... [+]
As is well recognized, serotonergic (5-HT) fibers distribute widely throughout the forebrain, including the amygdala. Although a few reports have examined the 5-HT innervation of select nuclei of the amygdala in the rat, no previous report has described overall 5-HT projections to the amygdala in the rat. Using immunostaining for the serotonin transporter, SERT, we describe the complete pattern of distribution of 5-HT fibers to the amygdala (proper) and to the extended amygdala in the rat. Based on its ontogenetic origins, the amygdala was subdivided into two major parts, pallial and subpallial components, with the pallial component further divided into superficial and deep nuclei (Olucha-Bordonau et al. 2015). SERT+ fibers were shown to distributed moderately to densely to the deep and cortical pallial nuclei, but, by contrast, lightly to the subpallial nuclei. Specifically, 1) of the deep pallial nuclei, the lateral, basolateral, and basomedial nuclei contained a very dense concentration of 5-HT fibers; 2) of the cortical pallial nuclei, the anterior cortical and amygdala–cortical transition zone rostrally and the posteromedial and posterolateral nuclei caudally contained a moderate concentration of 5-HT fibers; and 3) of the subpallial nuclei, the anterior nuclei and the rostral part of the medial (Me) nuclei contained a moderate concentration of 5-HT fibers, whereas caudal regions of Me as well as the central nuclei and the intercalated nuclei contained a sparse/light concentration of 5-HT fibers. With regard to the extended amygdala (primarily the bed nucleus of stria terminalis; BST), on the whole, the BST contained moderate numbers of 5-HT fibers, spread fairly uniformly throughout BST. The findings are discussed with respect to a critical serotonergic influence on the amygdala, particularly on the basal complex, and on the extended amygdala in the control of states of fear and anxiety. [-]
Palabras clave / Materias
Cita bibliográficaLinley, S. B., Olucha-Bordonau, F. and Vertes, R. P. (2017), Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat. J. Comp. Neurol., 525: 116–139. doi:10.1002/cne.24044
Tipo de documentoinfo:eu-repo/semantics/article
Derechos de acceso
2016 Wiley Periodicals, Inc.
Aparece en las colecciones
- MED_Articles 
Mostrando ítems relacionados por Título, autor o Palabra clave.
Differential efferent projections of the anterior, posteroventral, and posterodorsal subdivisions of the medial amygdala in mice Pardo-Bellver, Cecília; Cádiz-Moretti, Bernardita; Novejarque, Amparo; Martínez-García, Fernando; Lanuza, EnriqueThe medial amygdaloid nucleus (Me) is a key structure in the control of sociosexual behavior in mice. It receives direct projections from the main and accessory olfactory bulbs (AOB), as well as an important hormonal input. ...
Cádiz-Moretti, Bernardita; Abellán Álvaro, María; Pardo-Bellver, Cecília; Martínez García, Fernando; Lanuza, EnriqueThe transitional zone between the ventral part of the piriform cortex and the anterior cortical nucleus of the amygdala, named the cortex-amygdala transition zone (CxA), shows two differential features that allow its ...
The African striped mouse Lemniscomys barbarus as a model for aggression. Brain areas activated by agonistic encounters El Mlili, Nisrim; Boutoual, Rachid; Sánchez Pérez, Ana María; Ouarour, Ali; Chakir, Ibtissam; Errami, Mohammed; Olucha Bordonau, Francisco E.During agonistic behavior several brain areas became differentially activated depending on the role the subject is taking. Several areas are mostly activated during the offender role and several others are activated if the ...