Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
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Otros documentos de la autoría: Sorg, Barbara A.; Berretta, Sabina; Blacktop, Jordan; Fawcett, James W.; Kitagawa, Hiroshi; Kwok, Jessica C.F.; MIQUEL, MARTA
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Título
Casting a Wide Net: Role of Perineuronal Nets in Neural PlasticityAutoría
Fecha de publicación
2016-11Editor
Society for NeuroscienceCita bibliográfica
SORG, Barbara A., et al. Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. Journal of Neuroscience, 2016, vol. 36, no 45, p. 11459-11468.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.jneurosci.org/content/36/45/11459Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of ... [+]
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and after exposure to drugs of abuse. Here the focus is on how a major component of PNNs, chondroitin sulfate proteoglycans, control plasticity, and on the role of PNNs in memory in normal aging, in a tauopathy model of Alzheimer's disease, and in drug addiction. Also discussed is how altered extracellular matrix/PNN formation during development may produce synaptic pathology associated with schizophrenia, bipolar disorder, major depression, and autism spectrum disorders. Understanding the molecular underpinnings of how PNNs are altered in normal physiology and disease will offer insights into new treatment approaches for these diseases. [-]
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Journal of Neuroscience 9 November 2016, 36 (45)Derechos de acceso
Copyright © 2017 by the Society for Neuroscience
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