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dc.contributor.authorTresserra-Rimbau, Anna
dc.contributor.authorGuash-Ferré, Marta
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorToledo, Estefanía
dc.contributor.authorCorella, Dolores
dc.contributor.authorCastañer, Olga
dc.contributor.authorGuo, Xiaohui
dc.contributor.authorGómez Gracia, Enrique
dc.contributor.authorLapetra, José
dc.contributor.authorArós, Fernando
dc.contributor.authorFiol Ramis, Miquel
dc.contributor.authorRos, Emilio
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorPintó, Xavier
dc.contributor.authorFitó, Montserrat
dc.contributor.authorBabio, Nancy
dc.contributor.authorMartínez González, Miguel Ángel
dc.contributor.authorSorlí, José V
dc.contributor.authorLópez-Sabater, Maria Carmen
dc.contributor.authorEstruch, Ramon
dc.contributor.authorLamuela Raventós, Rosa María
dc.contributor.authorColtell, Oscar
dc.contributor.authorPREDIMED Investigators
dc.date.accessioned2017-04-25T07:52:04Z
dc.date.available2017-04-25T07:52:04Z
dc.date.issued2016-03
dc.identifier.citationTRESSERRA-RIMBAU, Anna, et al. Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly people at high cardiovascular disease risk. The Journal of nutrition, 2016, vol. 146, no 4, p. 767-777.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/167256
dc.description.abstractBackground: Higher consumption of some polyphenols has been associated with a reduced risk of diabetes. However, no studies have evaluated the relation between all polyphenol subclasses and the incidence of diabetes. Objective: We aimed to prospectively examine the associations between the intake of total polyphenols and different groups of polyphenols (flavonoids, phenolic acids, stilbenes, lignans, and others) on the risk of incident diabetes in the PREDIMED (Prevención con Dieta Mediterránea) trial. Methods: This was an observational cohort analysis of the nondiabetic participants in the PREDIMED trial. This study was a multicenter, controlled, randomized, parallel-group feeding trial to assess the effects of either a Mediterranean diet that was supplemented with extra-virgin olive oil or nuts or advice to adhere to a low-fat control diet on cardiovascular outcomes in elderly men and women at high cardiovascular disease risk. From the 7447 randomly assigned participants, 3430 were selected because they were free of diabetes at baseline and filled out the food-frequency questionnaires (FFQs). Polyphenol intake was calculated by matching food consumption data from repeated FFQs with the Phenol-Explorer database on the polyphenol content of each reported food. HRs and 95% CIs for diabetes according to tertiles of polyphenol intake were estimated with the use of time-dependent Cox proportional hazards models. Results: Over a mean of 5.51 y of follow-up (18,900 person-years), there were 314 new cases of diabetes. After multivariable adjustment, we observed a 28% reduction in new-onset diabetes in the highest compared with the lowest tertile of total polyphenol intake (HR: 0.72; 95% CI: 0.52, 0.99; P-trend = 0.05). The intake of subclasses of polyphenols also was inversely associated with diabetes risk, including for total flavonoids (HR: 0.67; 95% CI: 0.48, 0.93; P-trend = 0.02), stilbenes (HR: 0.57; 95% CI: 0.38, 0.84; P-trend = 0.003), dihydroflavonols (HR: 0.59; 95% CI: 0.40, 0.88; P-trend = 0.003), and flavanones (HR: 0.69; 95% CI: 0.49, 0.97; P-trend = 0.03). Conclusions: A high intake of total polyphenols, total flavonoids (specifically flavanones and dihydroflavonols), and stilbenes is associated with a reduced risk of diabetes in elderly persons at high risk of cardiovascular disease. This trial was registered at http://www.controlled-trials.com as ISRCTN35739639.ca_CA
dc.description.sponsorShipThis study was supported by The Interministerial Commission on Science and Technology, CICYT (AGL2013-49083-C3-1-R) from the Spanish Ministry of Economy and Competitiviness, the Generalitat de Catalunya (2014 SGR 773), and the Instituto de Salud Carlos III (ISCIII) (CIBEROBN). CIBEROBN is an initiative of ISCIII, Spain. AT-R received support from ISCIII (FI10/00265). The Fundación Patrimonio Comunal Olivarero, the California Walnut Commission, Borges SA, and Morella Nuts SA donated the olive oil, walnuts, almonds, and hazelnuts, respectively, used in the study.ca_CA
dc.format.extent10 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherAmerican Society for Nutritionca_CA
dc.relation.isPartOfJ. Nutr. April 2016, vol. 146, no. 4ca_CA
dc.rights© 2016 American Society for Nutritionca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectchronic diseaseca_CA
dc.subjectcox regressionca_CA
dc.subjectepidemiologyca_CA
dc.subjectglucoseca_CA
dc.subjectobservational studyca_CA
dc.titleIntake of Total Polyphenols and Some Classes of Polyphenols Is Inversely Associated with Diabetes in Elderly People at High Cardiovascular Disease Riskca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/ 10.3945/​jn.115.223610
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://jn.nutrition.org/content/146/4/767.shortca_CA


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