Mostrar el registro sencillo del ítem

dc.contributor.authorSánchez-Sarasúa, Sandra
dc.contributor.authorMoustafa, S.
dc.contributor.authorGarcía Avilés, Álvaro
dc.contributor.authorLópez Climent, María Fernanda
dc.contributor.authorGomez-Cadenas, Aurelio
dc.contributor.authorOlucha-Bordonau, Francisco E
dc.contributor.authorSánchez-Pérez, Ana María
dc.date.accessioned2016-12-12T11:57:49Z
dc.date.available2016-12-12T11:57:49Z
dc.date.issued2016-10
dc.identifier.citationSÁNCHEZ-SARASÚA, Sandra, et al. The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation. Nutrition & Metabolism, 2016, vol. 13, no 1, p. 73.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/164999
dc.description.abstractBackground Western diet and lifestyle are associated with overweight, obesity, and type 2 diabetes, which, in turn, are correlated with neuroinflammation processes. Exercise and a healthy diet are important in the prevention of these disorders. However, molecules inhibiting neuroinflammation might also be efficacious in the prevention and/or treatment of neurological disorders of inflammatory etiology. The abscisic acid (ABA) is a phytohormone involved in hydric-stress responses. This compound is not only found in plants but also in other organisms, including mammals. In rodents, ABA can play a beneficial role in the regulation of peripheral immune response and insulin action. Thus, we hypothesized that chronic ABA administration might exert a protective effect in a model of neuroinflammation induced by high-fat diet (HFD). Methods Male Wistar rats were fed with standard diet or HFD with or without ABA in the drinking water for 12 weeks. Glucose tolerance test and behavioral paradigms were performed to evaluate the peripheral and central effects of treatments. One-Way ANOVA was performed analyzed statistical differences between groups. Results The HFD induced insulin resistance peripherally and increased the levels of proinflammatory markers in in the brain. We observed that ABA restored glucose tolerance in HFD-fed rats, as expected. In addition, chronic ABA treatment rescued cognitive performance in these animals, while not affecting control diet fed animals. Moreover, it counteracted the changes induced by HFD in the hypothalamus; microglia activations and TNFα mRNA levels. Conclusion These results suggest that ABA might become a new therapeutic molecule improving the neuroinflammatory status and insulin resistance.ca_CA
dc.description.sponsorShipThis work was supported by Plan Propi Universitat Jaume I P1.1A2014-06 and GVA AICO/2015/042 to AMSP.ca_CA
dc.format.extent11 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherBioMed Centralca_CA
dc.relation.isPartOfNutrition & Metabolism, 2016, vol. 13, no 1ca_CA
dc.rights© 2016 BioMed Central Ltd unless otherwise stated. Part of Springer Nature.ca_CA
dc.rightsAtribución 4.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectobesityca_CA
dc.subjectworking memoryca_CA
dc.subjectmicrogliaca_CA
dc.subjectphytohormonesca_CA
dc.titleThe effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammationca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1186/s12986-016-0137-3
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0137-3ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


Ficheros en el ítem

Thumbnail
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

© 2016 BioMed Central Ltd unless otherwise stated. Part of Springer Nature.
Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2016 BioMed Central Ltd unless otherwise stated. Part of Springer Nature.